Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Biofilms formation on polymeric materials for drinking water pipes

ABSTRACT: Biofilms on polymeric pipes

PROVIDER: PRJEB87778 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR14790232_1.fastq.gz	Fastqsanger.gz
	ERR14790232_2.fastq.gz	Fastqsanger.gz
	ERR14790233_1.fastq.gz	Fastqsanger.gz
	ERR14790233_2.fastq.gz	Fastqsanger.gz
	ERR14790234_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 56

Similar Datasets

Drinking water biofilms

Project description:Dosing phosphate effect on drinking water biofilms

| PRJNA656940 | ENA

Drinking water biofilms

Project description:Effect of phophate on drinking water Biofilms

| PRJNA656697 | ENA

Drinking water biofilms

Project description:Drinking water biofilms (lead) Raw sequence reads

| PRJNA663268 | ENA

Biofilms of drinking water pipes

Project description:Prokaryotic and eukaryotic diversity in biofilms from pipes of hot drinking water distribution network assessed by sequencing of 16S and 18S rRNA gene amplicons

| PRJEB27134 | ENA

drinking water and biofilms

Project description:drinking water and biofilms Raw sequence reads

| PRJNA643656 | ENA

Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms

Project description:Safe and efficient antibacterial materials are urgently needed to combat drug-resistant bacteria and biofilm-associated infections. The rational design of nanoparticles for flexible elimination of biofilms by alternative strategies remains challenging. Herein, we propose the fabrication of Janus-structured nanoparticles targeting extracellular polymeric substance to achieve dispersion or near-infrared (NIR) light-activated photothermal elimination of drug-resistant biofilms, respectively. Asymmetrical Janus-structured dextran-bismuth selenide (Dex-BSe) nanoparticles are fabricated by a facile strategy to exploit synergistic effects of both components. The biocompatible dextran domain with the maximum exposure endows the Janus nanoparticles with biofilm penetration, targeting, and dispersion functions. Interestingly, Janus Dex-BSe nanoparticles realize enhanced dispersal of biofilms over time compared with dextran nanoparticles while the underlying molecular mechanisms are further revealed by RNA-sequencing transcriptomics analysis. Alternatively, taking advantage of the preferential accumulation of nanoparticles at infection sites, the self-propelled active motion induced by the unique Janus structure enhances the photothermal killing effect under NIR light irradiation, thereby eradicating the biofilm. Given these favorable features, the antibiofilm activity of Janus Dex-BSe against methicillin-resistant Staphylococcus aureus (MRSA) was first validated in vitro. More importantly, the flexible application of Janus Dex-BSe nanoparticles for biofilm removal or NIR-triggered eradication in vivo was demonstrated by MRSA-infected mouse excisional wound model and abscess model, respectively. The currently developed Janus nanoplatform holds great promise for the efficient elimination of drug-resistant biofilms in diverse antibacterial scenarios.

2023-08-01 | GSE239411 | GEO

Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms

Project description:Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms

| PRJNA999229 | ENA

Vitamin C inhibits bacterial biofilms by affecting the synthesis of the extracellular polymeric matrix

Project description:Extracellular polymeric substances (EPS) produced by bacteria form a matrix for the complex three-dimensional architecture of biofilms. The EPS matrix of a biofilm is primarily composed of polysaccharides, proteins and extracellular DNA (eDNA). In addition to supporting the community structure, the EPS matrix protects bacterial biofilms from the environment. Specifically, the EPS matrix reduces the penetration of antimicrobial agents into the biofilm, thereby reducing their efficiency. Strategies for disrupting the formation of the EPS matrix can therefore lead to a more efficient use of antimicrobial agents. Here, we examine the biofilm-disrupting activity of vitamin C (sodium ascorbate). Quantitative proteomics analysis of vitamin C treated biofilms show that exposure to vitamin C inhibits quorum sensing and other regulatory mechanisms underpinning biofilm development. This results in inhibition of the EPS biosynthesis, and depletion of the polysaccharide component of the matrix. Once the EPS content is reduced beyond a critical point, bacterial cells get fully exposed to the medium, thereby experiencing a planktonic-like state. At this stage, the cells are more susceptible to killing, either by vitamin C-induced oxidative stress as reported here, or by other antibacterial compounds or treatments.

2017-12-19 | PXD007533 | Pride

drinking water microbiome

Project description:Nutrient-based selection in building plumbing biofilms

| PRJNA633020 | ENA

drinking water metagenome

Project description:Comparison of disinfectants on water-derived biofilms.

| PRJNA614901 | ENA