Project description:Experimental autoimmune uveitis (EAU) in Lewis rats is a model for the clinical heterogeneity of human uveitis. The autoantigens inducing disease in the rat are also seen in human disease. Depending upon the specific autoantigen used, the experimental disease course can be either monophasic or relapsing/remitting and appears to be dictated by the T cell effector phenotype elicited. We investigated potential differences between monophasic and relapsing/remitting effector T cells using transcriptomic profiling and pathway analysis. RNA samples isolated from three independent T cell lines derived from each specificity where analyzed by microarrays. Microarray data was used to obtain transcriptomic changes reflecting signal transduction pathway dysregulation. Keywords: Two group comparison

2010-12-01 | GSE19652 | GEO

Adenosma indiana

Project description:Adenosma indiana Genome sequencing

| PRJNA1036732 | ENA

Mali iNTS - monophasic Typhimurium

Project description:Mali iNTS - monophasic Typhimurium

| PRJEB2164 | ENA

monophasic variant of Salmonella Typhimurium outbreak in France 2020

Project description:monophasic variant of Salmonella Typhimurium outbreak in France 2020

| PRJEB40826 | ENA

Effector T cells driving monophasic vs relapse/remitting experimental autoimmune uveitis show unique pathway signatures

2010-12-01 | E-GEOD-19652 | biostudies-arrayexpress

Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.

Project description:A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher k cat/Km ratios for cefotaxime. The genetic environment of bla NDM-13 was determined to be tnpA-IS30-bla NDM-13-ble MBL-trpF-dsbC-cutA-groES-groL, with bla NDM-13 located within the chromosome.

| S-EPMC4538491 | biostudies-literature

Decay of NDM-positive E. coli

Project description:Fate and persistence of a pathogenic NDM-1-positive Escherichia coli strain in anaerobic and aerobic sludge microcosms

| PRJEB14387 | ENA