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Genome-Wide CRISPRi Screen and Proteomic Profiling Identify Key Genes Related to Ferulic Acid's Antifungal Activity

ABSTRACT: Genome-Wide CRISPRi Screen and Proteomic Profiling Identify Key Genes Related to Ferulic Acid's Antifungal Activity

PROVIDER: PRJEB95957 | ENA |

REPOSITORIES: ENA

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Genome-Wide CRISPRi Screen and Proteomic Profiling Identify Key Genes Related to Ferulic Acid's Antifungal Activity

Project description:Genome-Wide CRISPRi Screen and Proteomic Profiling Identify Key Genes Related to Ferulic Acid's Antifungal Activity

| PRJEB94852 | ENA

Genome-Wide CRISPRi Screen and Proteomic Profiling Identify Key Genes Related to Ferulic Acid's Antifungal Activity

Project description:Genome-Wide CRISPRi Screen and Proteomic Profiling Identify Key Genes Related to Ferulic Acid's Antifungal Activity

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Ferulic Acid Challenge of Lactobacillus brevis

Project description:The presence of anti-microbial phenolic compounds, such as the model compound ferulic acid, in biomass hydrolysates poses significant challenges to the widespread use of biomass in conjunction with whole cell biocatalysis or fermentation. Currently, these inhibitory compounds must be removed through additional downstream processing to create feedstock suitable for most industrially important microbial strains. This study explores the high ferulic acid tolerance in Lactobacillus brevis (L. brevis), a lactic acid bacteria often found in fermentation processes, by global transcriptional response analysis. The transcriptional profile of L. brevis under ferulic acid stress reveals that the presence of ferulic acid primarily triggers the expression of membrane proteins to counteract ferulic acid induced changes in membrane fluidity and ion leakage, in the midst of a generalized stress response. Several promising routes for understanding phenolic acid tolerance have been identified based upon these findings. These insights may be used to guide further engineering of model industrial organisms to better tolerate phenolic compounds in processed biomass.

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Expression data from ferulic acid treated C. elegans

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Global transcriptomic analysis of the response of Corynebacterium glutamicum to ferulic acid

Project description:Corynebacterium glutamicum can survive by using ferulic acid as the sole carbon source. In this study, we assessed the response of C.glutamicum to ferulic acid stress by means of a global transcriptional response analysis. The transcriptional data showed that several genes involved in degradation of ferulic acid were affected. Moreover, several genes related to the stress response; protein protection or degradation and DNA repair; replication, transcription and translation; and the cell envelope were differentially expressed. Deletion of the katA or sigE gene in C. glutamicum resulted in a decrease in cell viability under ferulic acid stress. These insights will facilitate further engineering of model industrial strains, with enhanced tolerance to ferulic acid to enable easy production of biofuels from lignocellulose.

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CRISPRi screen of prostate cancer associated risk cis-regulatory elements [CRISPRi]

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Effect of ferulic acid on Clostridium beijerinckii NCIMB 8052 transcriptome

Project description:The impacts of ferulic acid, a phenolic compound commonly found in lignin hydrolysates, on the growth, solvent production and transcriptional responses of C. beijerinckii NCIMB 8052 were determined. Addition of ferulic acid to growing cultures resulted in a decrease in the growth and solvent production by 30 and 25%, respectively, when compared to the control cultures. To better understand the toxicity of this compound, microarray analyses were performed using samples taken from these cultures at three different growth states. Several gene ontology terms and KEGG pathways were identified showing significant change at each status, including ABC transporters, two component system and oxidoreductase activity. Moreover, genes related with efflux systems and heat shock proteins were also strongly up- regulated. Among these, expression of the groESL operon was induced by more than 4-fold and was consequently selected for overexpression to improve C. beijerinckii tolerance to ferulic acid.

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