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Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

ABSTRACT: Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

PROVIDER: PRJEB9615 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR912634.fastq.gz	Fastqsanger.gz
	ERR912635.fastq.gz	Fastqsanger.gz
	ERR912636.fastq.gz	Fastqsanger.gz
	ERR912637.fastq.gz	Fastqsanger.gz
	ERR912638.fastq.gz	Fastqsanger.gz

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Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

Project description:Total RNA from ileum of three groups of mice are sequenced. The three groups are 1. wild type mice. 2. mice with IFNg gene knockout. 3. IFNg gene knockout mice after colonization of Akkermansia muciniphila

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Akkermansia muciniphila outer membrane protein Amuc_0904 promotes goblet cell differentiation

Project description:Akkermansia muciniphila is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of A. muciniphila in regulating intestinal homeostasis remain to be explored. Here, we discovered that A. muciniphila was dramatically increased during colitis recovery, and its colonization greatly increased goblet cells to protect the intestinal barrier in mice. Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, was identified to induce goblet cell differentiation.

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Project description:Akkermansia muciniphila, a common member of the human gut microbiota, is considered to be a beneficial resident of the intestinal mucus layer. Surface-exposed molecules produced by this organism likely play important roles in colonization and communication with other microbes and the host, but the protein composition of the outer membrane has not been characterized thus far. Herein we identify A. muciniphila proteins after enrichment and fractionation of the outer membrane proteome of A. muciniphila.

2016-09-27 | PXD004400 | Pride

Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression

Project description:We implemented transcriptomic analyses of blood and hippocampus of old mice treated with Akkermansia muciniphila Membrane Protein for 8 weeks.

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Project description:Akkermansia muciniphila Raw sequence reads

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