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TIE2 mutations in VM

ABSTRACT: Venous Malformation: from causative TIE2 mutations to murine model and targeted therapy

PROVIDER: PRJEB9698 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR929318.fastq.gz	Fastqsanger.gz
	ERR929319.fastq.gz	Fastqsanger.gz
	ERR929320.fastq.gz	Fastqsanger.gz
	ERR929321.fastq.gz	Fastqsanger.gz
	ERR929322.fastq.gz	Fastqsanger.gz

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Expression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB

Project description:Comparison of transcriptional profiles of human umbilical vein endothelial cells (HUVECs) expressing wild-type vs. VM-causative mutant forms of TIE2/TEK. The effects of the most common Venous Malformation-causative mutations in the endothelial cell tyrosine kinase receptor: R849W and L914F, were tested. 743 genes were differentially expressed across the four groups. The 80 genes distinguishing between L914F and wild-type TIE2-expressing HUVECs were analyzed in greater detail. 3 batches each of: non-transfected, and wild-type TIE2, R849W-TIE2, and L914F-TIE2 overexpressing HUVECs were compared by exon-array profiling.

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