Project description:Classical ecotoxicological test and high-throughput molecular tools (microarray) were conducted on C. elegans to assess the effectiveness and ecosafety of a nanoremediation strategy applied to a highly polluted soil environment with heavy metals (HMs). We stablished a profiled gene expression in C. elegans exposed to the polluted soil, treated and untreated with nZVI. The results obtained showed that the percentage of differentially expressed genes decreased with the exposure time to nZVI. The expression profile of genes associated with stress response, metal toxicity, proteolysis, immune response, and cuticle development resulted affected. At short term, when a more effective HMs immobilization has occurred genes related to specific heavy metal detoxification mechanisms or to response to metal stress, were down regulated. After longer exposure time, we found decreased effectiveness of nZVI and increased HMs toxicity, whereas the transcriptional oxidative and metal-induced responses were attenuated.

2022-01-24 | GSE145995 | GEO

Enterobacter ludwigii strain:Heavy metal | isolate:Heavy metal

Project description:Enterobacter ludwigii strain:Heavy metal | isolate:Heavy metal Genome sequencing

| PRJNA1275621 | ENA

Expression analysis of Cupriavidus metallidurans CH34 in presence of heavy metals

Project description:Cupriavidus metallidurans CH34 is a metal resistant beta-proteobacterium. The genome of this bacterium contain many genes involved in heavy metal resistance. Gene expression of C. metallidurans was studied after the addition of of Zn(II), Cd(II), Cu(II), Ni(II), Pb(II), Hg(II) or Co(II). Keywords: Heavy metal stress response

2007-03-16 | GSE7272 | GEO

Microbial Removal of Heavy Metals from Contaminated Environments Using Metal-Resistant Indigenous Strains.

Project description:Contamination of soil with heavy metals has become a matter of global importance due to its impact on agriculture, environmental integrity, and therefore human health and safety. Several microbial strains isolated from soil contaminated by long-term chemical and petrochemical activities were found to manifest various levels of tolerance to Cr, Pb, and Zn, out of which Bacillus marisflavi and Trichoderma longibrachiatum exhibited above-moderate tolerance. The concentrations of target heavy metals before and after bioremediation were determined using electrochemical screen-printed electrodes (SPE) modified with different nanomaterials. The morpho-structural SEM/EDX analyses confirmed the presence of metal ions on the surface of the cell, with metal uptake being mediated by biosorption with hydroxyl, carboxyl, and amino groups as per FTIR observations. T. longibrachiatum was observed to pose a higher bioremediation potential compared to B. marisflavi, removing 87% of Cr and 67% of Zn, respectively. Conversely, B. marisflavi removed 86% of Pb from the solution, compared to 48% by T. longibrachiatum. Therefore, the fungal strain T. longibrachiatum could represent a viable option for Cr and Zn bioremediation strategies, whereas the bacterial strain B. marisflavi may be used in Pb bioremediation applications.

| S-EPMC10801475 | biostudies-literature

LATS regulates heavy metal response

Project description:LATS regulates heavy metal response

| PRJNA685123 | ENA

LATS regulates heavy metal response

Project description:Heavy metals are essential integral parts of cells and environmental toxicants, whose deregulation is associated with severe cellular dysfunction and various diseases. The Hippo pathway plays a critical role in organ size control and cancer development. In this study, we use RNA-Seq to investigate the role of the Hippo pathway in regulating heavy metal response gene transcription. Specifically, the difference of transcriptional profiles between the wild-type and the Hippo pathway kinases LATS1/2-deficient HEK293A cells was examined under control- and heavy metals zinc and cadimuim treated-conditions.

2021-10-02 | GSE163156 | GEO

Transcriptomic response of Elodea nuttallii to heavy metals

Project description:The mechanisms of heavy metal accumulation in primary producers and the damage and stress response induced by heavy metals is not well understood. We used UHTS to analyze the transcriptomic response of Elodea nuttallii to heavy metal pollution. We exposed shoots of E. nuttallii for 24 h to increasing concentrations of Hg and Cd. Using Illumina RNA-Seq, we have generated over 50 million 54 nt paired end reads and 14 million single end reads, which we used for de novo assembly of the E. nuttallii transcriptome.

2012-02-01 | E-MTAB-892 | biostudies-arrayexpress

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