Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mycobacterium tuberculosis XDR case with bedaquiline and delamanid resistance WGS study

ABSTRACT: Mycobacterium tuberculosis XDR case with bedaquiline and delamanid resistance WGS study

PROVIDER: PRJEB9936 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR978256_1.fastq.gz	Fastqsanger.gz
	ERR978256_2.fastq.gz	Fastqsanger.gz
	ERR978257_1.fastq.gz	Fastqsanger.gz
	ERR978257_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

WGS of an XDR Salmonella typhi italian isolate

Project description:Miseq WGS of an XDR Salmonella typhi italian isolate

| PRJEB35582 | ENA

Unveiling the response of efflux pump genes to delamanid in Mycobacterium tuberculosis H37Rv: transcriptomic analysis.

Project description:Efflux pump overexpression is associated with drug resistance in Mycobacterium tuberculosis, but its role in delamanid resistance is not well understood. This study sought to identify efflux pump genes affected by delamanid exposure using transcriptomic analysis. Cultures of M. tuberculosis H37Rv were exposed to delamanid at a sub-inhibitory concentration of ½ MIC for 24 hours, and transcriptomic sequencing was conducted on both treated and untreated samples. Differentially expressed genes (DEGs) were annotated using the UniProt database. The analysis revealed significant upregulation of 23 efflux pump genes under delamanid stress, with 73.9% belonging to the ABC family, 17.39% to the RND family, and 8.69% to the MFS superfamily. These results highlight efflux pump genes that are responsive to sub-inhibitory levels of delamanid.

2026-04-30 | GSE287913 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Delamanid

Project description:To understand the response of M. tuberculosis (MTB) to the drug delamanid, we performed transcriptomics on MTB bacilli exposed to the drug.

2018-08-02 | GSE118008 | GEO

Bedaquiline and Clofazimine Resistance determinants

Project description:WGS of bedaquiline and clofazimine resistant MTBC mutants

| PRJEB44524 | ENA

Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain in the presence of the drug Delamanid

Project description:In this study, the transcriptional response of two Mycobacterium tuberculosis strains to a pressure of the recently approved delamanid is investigated. RNA sequencing revealed that the response to this bicyclic nitroimidazole shows many similarities with the anti-tuberculous drug from the same class pretomanid. Although delamanid is found to inhibit cell wall synthesis, the expression of genes involved in this process were only mildly affected. In contrast, a clear parallel was found with components that affect aerobic respiration. This demonstrates that respiratory poisoning plays a fundamental role in the bactericidal effect of delamanid. Remarkably, the most highly induced genes comprise poorly characterized genes for which functional characterization might hint to the target molecule(s) of delamanid and its exact mode of action.

2019-10-31 | GSE123294 | GEO

Transcriptional Response of Mycobacterium tuberculosis H37Rv to Bedaquiline

Project description:Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to bedaquiline, we performed transcriptomics over a time-course on MTB bacilli exposed to the drug.

2016-05-05 | GSE72459 | GEO

Bedaquiline-induced transcriptional response of Mycobacterium smegmatis mc2 155

2015-04-06 | GSE59871 | GEO

XDR-TB

Project description:XDR-TB

| PRJEB86592 | ENA

First case of extensively drug-resistant tuberculosis treated with both delamanid and bedaquiline.

Project description: Not available

| S-EPMC5007220 | biostudies-literature

Bedaquiline-induced transcriptional response of Mycobacterium smegmatis mc2 155

Project description:Transcriptional profiling of M. smegmatis mc2155 grown on Hartmans de Bont (HdB) supplemented with 0.2% glycerol and 0.05% Tween80 challenged with 2 μg/ml Bedaquiline and Dimethyl sulfoxide (DMSO) Two-condition experiment. Biological replicates: 5 independently grown and harvested. One replicate per array.

2015-04-06 | E-GEOD-59871 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data