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Transcriptome-wide m6A methylation of Wuhua yellow-feathered chicken ovary revealed potential molecular mechanisms underlying the low egg performance

ABSTRACT: Transcriptome-wide m6A methylation of Wuhua yellow-feathered chicken ovary revealed potential molecular mechanisms underlying the low egg performance

PROVIDER: PRJNA1000480 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25473506_1.fastq.gz	Fastqsanger.gz
	SRR25473506_2.fastq.gz	Fastqsanger.gz
	SRR25473507_1.fastq.gz	Fastqsanger.gz
	SRR25473507_2.fastq.gz	Fastqsanger.gz
	SRR25473508_1.fastq.gz	Fastqsanger.gz

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Project description:Butyrate has been reported to promote the performance and growth of chickens. The specific roles and efficacy of different sources of butyrate remained unclear. Thus, the present study aimed to investigate and compare the effects of Clostridium butyricum (CB), sodium butyrate (SB), and butyric acid glycerides (tributyrin, BAG) on the reproductive performance, egg quality, intestinal health, and offspring performance of yellow-feathered breeder hens. A total of 300 Lingnan yellow-feathered breeder hens were assigned to five treatment groups: control (CL), 1×108CFU/kg CB (CBL), 1×109CFU/kg CB (CBH), 500mg/kg SB, and 300mg/kg BAG. Results showed that the laying performance and egg quality were increased by CBL, CBH, and BAG. Both CB treatments increased the hatchability of fertilized eggs. Maternal supplementation with both levels of CB significantly elevated the growth performance of offspring. Treatment with CBL, CBH, SB, and BAG all improved the oviduct-related variables and reduced the plasmal antioxidant variables. The CBH, CBL, and BAG treatments also improved the intestinal morphology to different degrees. Jejunal contents of IL-6 were decreased by CBH and BAG, while those of IL-4, IL-6, IL-1β, and IgY were decreased by SB. Transcripts of nutrient transporters in jejunal mucosa were also upregulated by CBH, CBL, and SB treatments and expression of Bcl-2-associated X protein was decreased by CBL, CBH, and BAG. In cecal contents, CBL increased the abundance of Firmicutes and Bacillus, while CBH decreased the abundance of Proteobacteria. Also, the co-occurrence networks of intestinal microbes were regulated by CBH and BAG. In conclusion, dietary inclusion of CB and BAG improved the reproductive parameters, egg quality, and intestinal morphology of breeders. CB also influenced the hatching performance of breeders and growth performance of the offspring, while SB improved the oviduct-related variables. These beneficial effects may result from the regulation of cytokines, nutrient transporters, apoptosis, and gut microbiota; high-level CB had more obvious impact. Further study is needed to explore and understand the correlation between the altered gut microbiota induced by butyrate and the performance, egg quality, intestinal health, and also offspring performance.

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Transcriptome-wide m6A methylation of Wuhua yellow-feathered chicken ovary revealed potential molecular mechanisms underlying the low egg performance

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