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CD40 induces PIR-A+ macrophages to promote chronic rejection of cardiac transplantation

ABSTRACT: CD40 induces PIR-A+ macrophages to promote chronic rejection of cardiac transplantation

PROVIDER: PRJNA1000952 | ENA |

REPOSITORIES: ENA

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CD40 induces PIR-A+ macrophages to promote chronic rejection of cardiac transplantation

Project description:To investigate the mechanism PIR-A+ macrophages regulated by CD40 in chronic rejection of cardiac transplantation, we performed gene expression profiling analysis using data obtained from RNA-seq of bone marrow-derived macrophages stimulated with anti-CD40 mAb (FGK45) or IgG (Ctrl) for 24h.

2025-08-08 | GSE239774 | GEO

CD40 induces PIR-A+ macrophages to promote chronic rejection of cardiac transplantation [ChIP-seq]

Project description:CD40 induces PIR-A+ macrophages to promote chronic rejection of cardiac transplantation [ChIP-seq]

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CD40 induces PIR-A+ macrophages to promote chronic rejection of cardiac transplantation [ChIP-seq]

Project description:To explore whether transcription factor NF-κB2 interacts with the DNA region, NF-κB2 chip-seq studies, both in FGK45-treatment and IgG (Ctrl), were carried out to identify the direct target of NF-κB2.

2025-08-08 | GSE239816 | GEO

Donor Macrophages Modulate Rejection after Heart Transplantation

Project description:Cellular rejection after heart transplantation imparts significant morbidity and mortality. Current immunosuppressive strategies are imperfect, target recipient T-cells, and have adverse effects. The innate immune response plays an essential role in the recruitment and activation of T-cells. Targeting the donor innate immune response would represent the earliest interventional opportunity within the immune response cascade. There is limited knowledge regarding donor immune cell types and functions in the setting of cardiac transplantation and no current therapeutics exist for targeting these cell populations. Distinct populations of donor and recipient macrophages co-exist within the transplanted heart. Donor CCR2+ macrophages are key mediators of allograft rejection and deletion of MYD88 signaling in donor macrophages is sufficient to suppress rejection and extend allograft survival. This highlights the therapeutic potential of donor heart-based interventions.

2022-06-30 | GSE206801 | GEO

Molecular Characterization of Acute Cellular Rejection Occurring during Intentional Immunosuppression Withdrawal in Liver Transplantation

Project description:Acute cellular rejection occurs frequently during the first few weeks following liver transplantation. During this period its molecular phenotype is confounded by pro-inflammatory events elicited by surgery, ischemia-reperfusion injury and early post-transplant complications. To unambiguously define the molecular profile associated with rejection we collected sequential biological specimens from liver transplant patients at least 3 years after transplantation who developed rejection while enrolled in trials of intentional immunosuppression withdrawal Transcriptomic RISET 2.0 chips were employed using portal blood vein from 37 liver trasplant patients.Two timepoints were selected: before immunosupressive weaning and rejection time point.

2016-06-01 | E-GEOD-70305 | biostudies-arrayexpress

Donor Macrophages Modulate Rejection after Heart Transplantation

Project description:Donor Macrophages Modulate Rejection after Heart Transplantation

| PRJNA852221 | ENA

Molecular Characterization of Acute Cellular Rejection Occurring during Intentional Immunosuppression Withdrawal in Liver Transplantation

2016-06-01 | GSE70305 | GEO

Predicting Acute Cardiac Allograft Rejection Using Donor and Recipient Gene Expression

Project description:Acute rejection in cardiac transplant patients is still a contributing factor to limited survival of the implanted heart. Currently there are no biomarkers in clinical use that can predict, at the time of transplantation, the likelihood of post-transplantation acute rejection, which would be of great importance for personalizing immunosuppressive treatment. Within the Biomarkers in Transplantation initiative, the predictive biomarker discovery focused on data and samples collected before or during transplantation such as: clinical variables, genes and proteins from the recipient, and genes from the donor. Based on this study, the best predictive biomarker panel contains genes from the recipient whole blood and from donor endomyocardial tissue and has an estimated area under the curve of 0.90. This biomarker panel provides clinically relevant prediction power and may help personalize immunosuppressive treatment and frequency of rejection monitoring.

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A single cell analysis of allograft rejection and tolerance using mouse solid organ transplantation models

Project description:Solid organ transplantation in the mouse is a powerful research tool that has provided a pathway to find important mechanistic insights into the regulation of allograft injury, allograft immunopathology, and transplant rejection/tolerance, and that has unique advantages over transplantation in larger species, due to the well characterization of mouse genome and availability of genetically modified animals. However, setup of mouse liver, heart and kidney transplantation is a technically demanding surgical procedure, especially the orthotopic liver transplantation in mouse. Here, we performed Microwell-based single cell RNA-seq of three mouse organ transplantation models (liver, heart and kidney). Comparison of lymphocytes, parenchyma cells and peripheral blood mononuclear cells in liver, heart and kidney revealed distinct immune microenvironment at acute rejection and tolerance state respectively. Single-cell transcriptome analysis of mouse allograft without immunosuppressive drugs provided rich resources to help understand functioning solid-organ transplantation in human.

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Microarray screening for microRNAs differentially expressed in whole blood samples of patients with clinically significant rejection after liver transplantation

Project description:To investigate whether differentially expressed microRNAs in peripheral blood could be associated with clinically significant, histologically proven acute cellular rejection after liver transplantation, a microRNA microarray screening was performed with RNA isolated from PaxGene whole blood samples from patients with ACR within the first three postoperative weeks and from patients without clinical signs of rejection within the first 6 months after transplantation.

2016-12-24 | GSE65492 | GEO

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