Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional differences in breast cancer cells exposed to acute versus chronic hypoxia.

ABSTRACT: Transcriptional differences in breast cancer cells exposed to acute versus chronic hypoxia.

PROVIDER: PRJNA1002981 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25548824.fastq.gz	Fastqsanger.gz
	SRR25548825.fastq.gz	Fastqsanger.gz
	SRR25548826.fastq.gz	Fastqsanger.gz
	SRR25548827.fastq.gz	Fastqsanger.gz
	SRR25548828.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Transcriptional differences in breast cancer cells exposed to acute versus chronic hypoxia.

Project description:Our previous studies demonstrated that exposing cells to acute hypoxic conditions in vitro (24 h at 1% oxygen) does not fully recapitulate exposure to intratumoral hypoxia (Godet et al., 2019). In this study, we sought to investigate whether chronic exposure to hypoxia in vitro (10 days at 1% oxygen) would better mimic the transcriptional effects of intratumoral hypoxia.

2023-09-01 | GSE240211 | GEO

Gene expression of Mus exposed to chronic hypoxia

2009-04-30 | GSE15891 | GEO

Transcriptome analysis of RNA from cancer cells exposed to chronic hypoxia versus normoxia

Project description:Transcriptome analysis of RNA from cancer cells exposed to chronic hypoxia versus normoxia

| PRJNA917511 | ENA

Transcription profiling of mouse exposed to chronic hypoxia

Project description:High altitude environments are characterized by the unique and unavoidable stress of chronic hypoxia. While much is known about gene expression responses to acute or in vitro hypoxia, less is known about the gene expression profiles of animals exposed to systemic chronic hypoxia, such as that experienced at high elevations. Here we simulated the hypoxic environment of two high altitude elevations,and a third chamber recieved ambient Reno air. Mice were housed in the hypoxic chambers for 32 days. We used microarrays to characterize the differential gene expression in the livers of mice housed in hypoxic environment of 4500 m versus 3000 and 1400 m. We used this data to draw hypotheses related to novel physiological responses to chronic systemic hypoxia Experiment Overall Design: Mice were housed one of three chambers; the first received ambient Reno air (1400 m) and the other two received air mixed with nitrogen such that one chamber simulated the hypoxic environment of 3000 m and the third chamber simulated hypoxic environment of 4500 m. Twelve mice were housed in each chamber for 32 days. Liver were extracted, and RNA from livers of 4 mice were pooled such that each treatment was represented by 3 pooled samples. Eight of the nine arrays were used for data analysis; one array was excluded as several Affymetrix quality control metrics indicated data quality that was not reliable.

2009-05-11 | E-GEOD-15891 | biostudies-arrayexpress

Transcriptional differences in suspended breast cancer cells exposed to hypoxia.

Project description:Transcriptional differences in suspended breast cancer cells exposed to hypoxia.

| PRJNA1119027 | ENA

Gene expression profile of HCT116 exposed to chronic hypoxia

Project description:To identify genes involved in survival to prolonged hypoxia we exposed HCT116 to hypoxia for 3 days. Control cells were exposed to normoxic conditions.

2013-01-18 | GSE43608 | GEO

Transcriptome analysis of RNA from cancer cells exposed to chronic hypoxia versus normoxia

Project description:Transcriptome data from six cancer cell lines passaged twenty times in normoxia (21% oxygen) or hypoxia (1% oxygen) Transcriptome analysis was conducted to determine the effect of chronic, long passaging, at 1% oxygen (hypoxia) on gene expression and alternative splicing in six cancer cell lines. The cancer cell lines included were two pancreatic (MIA PaCa-2, Capan-1), one lung (H226), one breast (MCF-7), one colon (HT-29), and one ovarian (SKOV-3). They were selected from a panel of 12 cancer cell lines since they showed the highest and lowest sensitivity to hypoxia based on their expression levels of a hypoxia 8-gene signature.

2023-03-29 | GSE222048 | GEO

Blood gene expression profile from mouse C57Bl/10 exposed to chronic hypoxia

Project description:In order to study the gene expression profile in C57Bl/10 mouse blood, we exposed three different groups of animals. First was exposed to PO2 21% or normoxia. The second was exposed to chronic hypoxia (from PO2 21% to PO2 8%) and the third was also exposed to the same chronic hypoxia (CH) protocol but followed by two weeks under normoxia, and called as recovery group. The blood was extracted from inferior vena cava, the RNA was extracted, amplified and hybridized to Affimetrix MOE 430 V2.o chip. The results were analyzed using Partek Genome suite software. Using two fold cuttoff and 0% FDR parameters, we observed genes 512 diferentially expressed, of which one gene was up-regulated in both hypoxic and recovery condition, 202 were up-regulated during CH and then down-regulated after the recovery, 18 genes were down-regulated afteh CH and the up-regulated after recovery, ans finally 9 genes were down-regulated in both CH and recovery conditions.

2012-05-26 | GSE17728 | GEO

Hypoxia-Induced Transcriptional Differences in African and Asian Versus European Diabetic Cybrids

Project description:Hypoxia-Induced Transcriptional Differences in African and Asian Versus European Diabetic Cybrids

| PRJNA871132 | ENA

Expression data of lung tissues of rats exposed to chronic hypoxia

Project description:Expression data of lung tissues of rats exposed to chronic hypoxia

| PRJNA527784 | ENA