Project description:PRM was performed to validate TMT-based quantification of Ganoderma lucidum dikaryon and monokaryons proteome to probe the profiles of different biological processes and their coordination that contribute to the dikaryon growth advantage.
Project description:Adoptive cell therapy (ACT) relies on durable and functional T cells to mediate tumor clearance. Th9 cells are a metabolically fit CD4⁺ T cell subset with strong persistence but limited cytotoxicity. Here, we identify Endomelipaneptide A (EpA), a cyclic peptide from Ganoderma lucidum–associated endophytic fungi, as a potent enhancer of Th9 differentiation. EpA promotes a cytotoxic Th9 phenotype with enhanced mitochondrial function and metabolic fitness.
2025-11-28 | GSE296515 | GEO
Project description:whole genome and transcriptome sequencing of Ganoderma lucidum CGMCC 5.616