Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative analysis of Cd61 high and Cd61 low populations of HSCs in M.musculus C97/Bl6 mice.

ABSTRACT: Comparative analysis of Cd61 high and Cd61 low populations of HSCs in M.musculus C97/Bl6 mice.

PROVIDER: PRJNA1004567 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25610155_1.fastq.gz	Fastqsanger.gz
	SRR25610155_2.fastq.gz	Fastqsanger.gz
	SRR25610156_1.fastq.gz	Fastqsanger.gz
	SRR25610156_2.fastq.gz	Fastqsanger.gz
	SRR25610157_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Comparative analysis of Cd61 high and Cd61 low populations of HSCs in M.musculus C97/Bl6 mice.

Project description:Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged HSCs. Here we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain self-renewal capacity in serial transplantations. A population of aged HSCs with highest CD61 expression is functionally comparable to young HSCs. These CD61High HSCs display a notably higher quiescence compared to their CD61Low counterparts. We also show that CD61High and CD61Low HSCs are transcriptomically distinct populations within aged HSCs. Collectively, our research identifies CD61 as a key player in maintaining stem cell quiescence during aging, ensuring the preservation of their functional integrity and potential. Moreover, CD61 emerges as a marker to prospectively isolate a superior, highly dormant population of young and aged HSCs, making it a valuable tool both in fundamental and clinical research.

2023-08-18 | GSE240650 | GEO

Low input RNA-seq of HSCs.

Project description:Low input RNA-seq of HSCs.

| PRJNA834789 | ENA

Low input RNA-seq of TMRM-High and TMRM-Low HSCs.

Project description:TMRM-High HSCs significantly enriched proteotoxic genes than TMRM-Low HSCs, in parallel to the differentially expressed carbon metabolism genes, cell cycle activation genes, and self-renewal genes.

2022-10-31 | GSE200343 | GEO

Low input RNA-seq of TMRM-High and TMRM-Low HSCs.

Project description:Low input RNA-seq of TMRM-High and TMRM-Low HSCs.

| PRJNA824123 | ENA

RNA sequencing of Mmrn1-high LT-HSCs and Mmrn1-low LT-HSCs from murine bone marrow

Project description:Mmrn1-high and Mmrn1-low LT-HSCs (lineage- Sca-1+ c-kit+ CD34- Flk2- cells) from murine bone marrow were isolated to explore the differentially expressed genes by RNA-seq.

2026-06-10 | GSE233828 | GEO

RNA sequencing of Mmrn1-high LT-HSCs and Mmrn1-low LT-HSCs from murine bone marrow

Project description:RNA sequencing of Mmrn1-high LT-HSCs and Mmrn1-low LT-HSCs from murine bone marrow

| PRJNA978057 | ENA

Transcriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.

Project description:Transcriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.

| PRJNA941818 | ENA

Characterization of E11.5 pre-HSCs and E12.5 & E14.5 HSCs to understand their transition using scRNA-seq

Project description:In oroder to understand the maturation process of pre-HSCs to HSC, we conducted scRNA-seq using E11.5pre-HSCs and E12.5&E14.5 LT_HSC populations. Pseudotime analysis and velocity analysis show the progression of pre-HSC to mature HSCs and also divergent point of lineage trajectory.

2023-02-13 | GSE182206 | GEO

Halomonas sp. BL6

Project description:Halomonas sp. BL6 Genome sequencing and assembly

| PRJNA546082 | ENA

Pseudomonas phage BL6

Project description:Pseudomonas aeruginosa Phage BL6 Raw sequence reads

| PRJNA1143577 | ENA