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Cardiac transcriptome analysis of right and left ventricular heart specimens of BBLN-transgenic mice by NGS

ABSTRACT: Cardiac transcriptome analysis of right and left ventricular heart specimens of BBLN-transgenic mice by NGS

PROVIDER: PRJNA1006067 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25658709_1.fastq.gz	Fastqsanger.gz
	SRR25658709_2.fastq.gz	Fastqsanger.gz
	SRR25658710_1.fastq.gz	Fastqsanger.gz
	SRR25658710_2.fastq.gz	Fastqsanger.gz
	SRR25658711_1.fastq.gz	Fastqsanger.gz

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Cardiac transcriptome analysis of right and left ventricular heart specimens of BBLN-transgenic mice by NGS

Project description:The study performed NGS to investigate the cardiac transcriptomes of right and left ventricular heart specimens of 3-4-month-old BBLN-transgenic mice with FVB/N background in comparison to those of non-transgenic FVB/N mice. BBLN-transgenic (Tg-BBLN) mice with myocardium-specific BBLN expression were generated to investigate the cardiac phenotype of increased cardiac BBLN transcript levels because the function of BBLN (Bublin coiled-coil protein), which is the chromosome 9 open reading frame(C9orf16), is largely unknown. Tg-BBLN mice with increased cardiac BBLN levels developed features of heart failure with increasing age. Pathomechanisms of heart failure induced by BBLN were investigated by NGS of right and left ventricular heart specimens of male, BBLN-transgenic mice (age: 3-4 months). NGS data reveal transcriptome changes in right and left ventricular heart specimens induced by increased expression of BBLN in the heart.

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