Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1006308 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR25661656_1.fastq.gz | Fastqsanger.gz | |||
| SRR25661656_2.fastq.gz | Fastqsanger.gz | |||
| SRR25661657_1.fastq.gz | Fastqsanger.gz | |||
| SRR25661657_2.fastq.gz | Fastqsanger.gz | |||
| SRR25661658_1.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 56 |
Similar Datasets
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction (MR) has been shown to improve metabolic health and extend lifespan. However, the effects of MR on the circadian clock and the underlying mechanisms have remained unclear. In this study, we discover that a methionine deprivation (MD) diet induces a remarkable reprogramming of hepatic circadian rhythms, with a profound impact on the oscillation of genes involved in the lipogenic pathway. Mechanistically, we demonstrate that the MD diet induces fluctuations of m6A mRNA methylation and reshapes the epigenetic landscape. Surprisingly, the rhythms of gut microbiota metabolism are reshaped by the MD diet, and the gut microbiota partially mediates the effects of the MD diet on hepatic circadian rhythms. Together, these findings provide compelling evidence that dietary methionine restriction remodels circadian rhythms through the modulation of gene expression, RNA methylation, histone modification, and microbiota metabolism.
2026-09-23 | GSE240880 | GEO
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction has been shown to improve metabolic health and extend lifespan. However, whether and how dietary methionine restriction impacts the circadian clock is unclear. Here, we demonstrate that methionine deprivation (MD) induces dramatic alterations in two signaling systems that input to the circadian clock: de novo oscillation of circulating FGF21 coupled with increased amplitude of glucocorticoid oscillations. These alterations in signaling result in a remarkable reprogramming of the hepatic circadian transcriptome and epigenetic landscape. The epigenetic and transcriptomic alterations result from dramatic remodeling of the rhythmic binding of the glucocorticoid receptor (GR) to chromatin as they are abolished by liver-specific deletion of GR. These results demonstrate that dietary methionine restriction remodels the circadian rhythms alterations in the biological program initiated by glucocorticoid receptor.
2026-09-23 | GSE288645 | GEO
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction has been shown to improve metabolic health and extend lifespan. However, whether and how dietary methionine restriction impacts the circadian clock is unclear. Here, we demonstrate that methionine deprivation (MD) induces dramatic alterations in two signaling systems that input to the circadian clock: de novo oscillation of circulating FGF21 coupled with increased amplitude of glucocorticoid oscillations. These alterations in signaling result in a remarkable reprogramming of the hepatic circadian transcriptome and epigenetic landscape. The epigenetic and transcriptomic alterations result from dramatic remodeling of the rhythmic binding of the glucocorticoid receptor (GR) to chromatin as they are abolished by liver-specific deletion of GR. These results demonstrate that dietary methionine restriction remodels the circadian rhythms alterations in the biological program initiated by glucocorticoid receptor.
2026-09-23 | GSE288644 | GEO
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction (MR) has been shown to improve metabolic health and extend lifespan. However, the effects of MR on the circadian clock and the underlying mechanisms have remained unclear. In this study, we discover that a methionine deprivation (MD) diet induces a remarkable reprogramming of hepatic circadian rhythms, with a profound impact on the oscillation of genes involved in the lipogenic pathway. Mechanistically, we demonstrate that the MD diet induces fluctuations of m6A mRNA methylation and reshapes the epigenetic landscape. Surprisingly, the rhythms of gut microbiota metabolism are reshaped by the MD diet, and the gut microbiota partially mediates the effects of the MD diet on hepatic circadian rhythms. Together, these findings provide compelling evidence that dietary methionine restriction remodels circadian rhythms through the modulation of gene expression, RNA methylation, histone modification, and microbiota metabolism.
2026-09-23 | GSE240877 | GEO
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction (MR) has been shown to improve metabolic health and extend lifespan. However, the effects of MR on the circadian clock and the underlying mechanisms have remained unclear. In this study, we discover that a methionine deprivation (MD) diet induces a remarkable reprogramming of hepatic circadian rhythms, with a profound impact on the oscillation of genes involved in the lipogenic pathway. Mechanistically, we demonstrate that the MD diet induces fluctuations of m6A mRNA methylation and reshapes the epigenetic landscape. Surprisingly, the rhythms of gut microbiota metabolism are reshaped by the MD diet, and the gut microbiota partially mediates the effects of the MD diet on hepatic circadian rhythms. Together, these findings provide compelling evidence that dietary methionine restriction remodels circadian rhythms through the modulation of gene expression, RNA methylation, histone modification, and microbiota metabolism.
2026-09-23 | GSE240875 | GEO
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction has been shown to improve metabolic health and extend lifespan. However, whether and how dietary methionine restriction impacts the circadian clock is unclear. Here, we demonstrate that methionine deprivation (MD) induces dramatic alterations in two signaling systems that input to the circadian clock: de novo oscillation of circulating FGF21 coupled with increased amplitude of glucocorticoid oscillations. These alterations in signaling result in a remarkable reprogramming of the hepatic circadian transcriptome and epigenetic landscape. The epigenetic and transcriptomic alterations result from dramatic remodeling of the rhythmic binding of the glucocorticoid receptor (GR) to chromatin as they are abolished by liver-specific deletion of GR. These results demonstrate that dietary methionine restriction remodels the circadian rhythms alterations in the biological program initiated by glucocorticoid receptor.
2026-09-23 | GSE288647 | GEO
Project description:The circadian clock tightly interacts with cellular metabolism, and nutritional challenges can profoundly remodel its function. Dietary methionine restriction has been shown to improve metabolic health and extend lifespan. However, whether and how dietary methionine restriction impacts the circadian clock is unclear. Here, we demonstrate that methionine deprivation (MD) induces dramatic alterations in two signaling systems that input to the circadian clock: de novo oscillation of circulating FGF21 coupled with increased amplitude of glucocorticoid oscillations. These alterations in signaling result in a remarkable reprogramming of the hepatic circadian transcriptome and epigenetic landscape. The epigenetic and transcriptomic alterations result from dramatic remodeling of the rhythmic binding of the glucocorticoid receptor (GR) to chromatin as they are abolished by liver-specific deletion of GR. These results demonstrate that dietary methionine restriction remodels the circadian rhythms alterations in the biological program initiated by glucocorticoid receptor.
2026-09-23 | GSE288646 | GEO
Project description:Ketone bodies, intermediates in energy metabolism and signaling, have attracted significant attention due to their role in health and disease. We performed around the clock study on ketone bodies and ketogenesis with mice on different diets. We found that caloric restriction, a dietary intervention that improves metabolism and longevity, induced high amplitude circadian rhythms in blood βOHB. The blood βOHB rhythms resulted from rhythmic ketogenesis in the liver controlled by the interaction between the circadian clock and PPAR transcriptional networks. This interaction results in transcriptional reprogramming of in beta-oxidation and ketogenesis enzymes. The reprogramming is impaired in circadian clock mutant mice. The circadian clock gated ketogenesis contributes to the diet impact on health and longevity.
2022-08-31 | GSE211975 | GEO
Project description:The feeding/fasting cycles controlled by our circadian clock impose great daily metabolic and physiological changes, and yet investigations into the consequences of metabolic deficiencies, either dietary or genetic, have often ignored the time of day or the circadian time of the animals or subjects. In addition, these deficiencies may themselves disrupt our circadian clock, causing secondary metabolic, physiological and behavioural disorders. Dietary methionine/choline deficiency in rodents is a common model for human non-alcoholic steatohepatitis, but methionine and choline are nutrients essential for many other processes beyond fatty acid synthesis in the liver, including biological methylations and 1-carbon metabolism, regulation of translation notably via the mTOR pathway, phospholipid synthesis, polyamine pathway and glutathione synthesis. We have previously shown that circadian rhythms in many organisms are highly sensitive to deficiency or excesses of 1-carbon metabolites. Using a methionine/choline deficient diet in mice, we illustrate the nutrigenomic crosstalk between circadian rhythms and 1-carbon metabolism. We show not only that circadian locomotor activity behaviour is profoundly, rapidly and reversibly affected by methionine/choline deficiency, but also that the effects of methionine/choline deficiency on gene expression and 1-carbon metabolites are dependent on circadian time, illustrating the importance of considering circadian rhythms in metabolic studies. This study also highlights the impact of what we eat, or don't, on our behaviour and biological rhythms.
2024-01-05 | GSE252364 | GEO
Project description:Caloric restriction extends lifespan and healthspan across species, with feeding times synchronized to circadian rhythms further maximizing its benefits. However, the mechanisms linking diet, diurnal rhythms, and lifespan are not fully understood. In mice, the time point most strongly tied to dietary effects on lifespan coincides with the peak of glucocorticoid secretion (ZT12, lights-off). Caloric restriction raises circulating glucocorticoid hormone levels, but their functional relevance remains untested. We show that the glucocorticoid receptor (GR) is critical for the effects of caloric restriction. Hepatocyte-specific GR mutant mice fail to respond to caloric restriction indicating that increased glucocorticoid amplitudes support its benefits. Using multiomics techniques in murine liver, we find that nutrient deprivation elicits a nuclear switch from active STAT signaling to increased FOXO1 activity, enabling the GR to activate a unique diet-specific gene expression program. Taken together, our results suggest that glucocorticoid rhythms are crucial for caloric restriction-induced metabolic reprogramming.
2025-11-04 | GSE248866 | GEO