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Transcriptome profile of fibroblast-like synoviocytes with FTO knockdown

ABSTRACT: Transcriptome profile of fibroblast-like synoviocytes with FTO knockdown

PROVIDER: PRJNA1007586 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25706823_1.fastq.gz	Fastqsanger.gz
	SRR25706823_2.fastq.gz	Fastqsanger.gz
	SRR25706824_1.fastq.gz	Fastqsanger.gz
	SRR25706824_2.fastq.gz	Fastqsanger.gz
	SRR25706825_1.fastq.gz	Fastqsanger.gz

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Transcriptome profile of fibroblast-like synoviocytes with FTO knockdown

Project description:Fibroblast-like synoviocytes (FLS) are crucial in promoting articular inﬂammation and destruction in rheumatoid arthritis (RA). As the most abundant RNA modification, the function of m6A in RA FLS is still unclear. Here, we constructed FTO-knockdown FLS to explore the mechanism of FTO in regulating the aggressive behavior of RA FLS.

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Project description:Fibroblast-like synoviocytes (FLS) harbour active migration, invasion, proliferation and decreased cell-contact inhibition, and served as a crucial component in pathogenesis of rheumatoid arthritis. However, the mechanism underlying the aggressive behavior remain unclear. In this study, we established FTO-knockdown RA FLS to investigate the molecular mechanism.

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Project description:To characterize transcriptome changes upon ATF6α knockdown by the siRNA in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs)

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Project description:LncRNA and mRNA microarrays were performed to identify differentially expressed lncRNAs and mRNAs in fibroblast-like synoviocytes from rheumatoid arthritis patients compared with fibroblast-like synoviocytes from trauma patients. Fibroblast-like synoviocytes were isolated from synovial tissues. LncRNA and mRNA microarrays were performed using fibroblast-like synoviocytes at passage 3.

2016-06-10 | E-GEOD-83147 | biostudies-arrayexpress

Effects of NCL Knockdown on Fibroblast-Like Synoviocytes

Project description:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation, synovial hyperplasia, and the destruction of bone and cartilage. Despite the use of various immunosuppressive disease-modifying antirheumatic drugs (DMARDs), a considerable proportion of RA patients remain symptomatic. As RA progresses, fibroblast-like synoviocytes (FLSs) undergo a phenotypic transition to an aggressive state, making them attractive non-immune cellular targets for RA treatment. However, there are currently no clinically available therapies that selectively ablate RA-FLSs due to the lack of specific molecular targets. Our research focuses on the knockdown of the nucleolin (NCL) gene in RA-FLSs. NCL is expressed in the cell of RA-FLSs and plays a crucial role in their aggressive transition. By specifically knocking down NCL, we observed significant inhibition of the harmful phenotypes exhibited by RA-FLSs.

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Project description:FTO-mediated RNA m6A demethylation regulates aggressive behavior and inflammation of fibroblast-like synoviocytes

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lncRNA and mRNA expression profiles in fibroblast-like synoviocytes from rheumatoid arthritis patients and trauma patients

Project description:Fibroblast-like synoviocytes (FLSs) are critical for synovial aggressiveness and joint destruction in rheumatoid arthritis (RA).The role and expression patterns of long noncoding RNAs (lncRNAs) in RA are largely unknown. We performed lncRNA and mRNA microarrays to identify differentially expressed lncRNAs and mRNAs in fibroblast-like synoviocytes from rheumatoid arthritis patients compared with fibroblast-like synoviocytes from trauma patients.

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