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Transcriptional and post-transcriptional control of odorant receptor choice in ants

ABSTRACT: Transcriptional and post-transcriptional control of odorant receptor choice in ants

PROVIDER: PRJNA1010363 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25782278_1.fastq.gz	Fastqsanger.gz
	SRR25782278_2.fastq.gz	Fastqsanger.gz
	SRR25782279_1.fastq.gz	Fastqsanger.gz
	SRR25782279_2.fastq.gz	Fastqsanger.gz
	SRR25782280_1.fastq.gz	Fastqsanger.gz

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Transcriptional and post-transcriptional control of odorant receptor choice in ants

Project description:We generated snRNA-Seq for olfactory sensory neurons from late stage pupae of the clonal raider ant to study the chemosensory gene expression during development.

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Commonality of Odorant Receptor Choice Mechanism Revealed by Analysis of a Highly Represented Odorant Receptor Transgene

Project description:In the mouse, more than 1,100 odorant receptors (ORs) are expressed in a monogenic and monoallelic fashion, referred to as singular gene expression. Using a 21bp singular-choice enhancer (x21), we radically increase representation of olfactory sensory neurons (OSNs) choosing a 5×21 enhanced OR transgene, but not overexpression of its mRNA on a per cell basis. RNA-sequencing and differential expression analysis identified 425 differentially expressed genes (DEGs). ORs make up 86% of all DEGs, of which 325 have decreased representation and 40 have increased representation. Underrepresented ORs include Class I, Class II and TAAR genes and within each of their respective olfactory bulb domains: DI, DII, and DIII (TAAR) we committedly observe multiple homogeneous glomeruli with an OR1A1-identity. The underrepresentation of endogenous, class-specific ORs across evolutionarily distinct cell types in favor of the expression of the 5×21-OR1A1 transgene argues that a common mechanism of singular gene choice is present for all OR-expressing OSNs

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A Common Mechanism of Singular Gene Choice is Revealed by Broadly Expressed Odorant Receptor Transgenes within the Olfactory Epithelium

Project description:In the mouse, more than 1,100 odorant receptors (ORs) are expressed in a monogenic and monoallelic fashion, referred to as singular gene expression. Here we utilize multimers of a naturally occurring 21bp enhancer (x21) and radically increase the number of olfactory sensory neurons (OSNs) choosing an OR transgene that is normally expressed by Class II cell types. Surprisingly, hundreds of ORs derived from Class I, Class II and TAAR cell types have reduced expression and are replaced by the OR transgene expression leading to novel glomeruli formed in three segregating domains of glomeruli on the olfactory bulb: DI (Class I), DII (Class II), and DIII (TAAR). The reduction of expression across distinct cell types that were thought to have distinct mechanisms of singular gene choice in favor of the expression of the x21-OR transgene argues that a common mechanism of singular gene choice is present for all OR-expressing OSNs.

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