Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Molecular Epidemiology of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella species in Tennessee Dairy Farms

PROVIDER: PRJNA1011909 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25897427_1.fastq.gz	Fastqsanger.gz
	SRR25897427_2.fastq.gz	Fastqsanger.gz
	SRR25897428_1.fastq.gz	Fastqsanger.gz
	SRR25897428_2.fastq.gz	Fastqsanger.gz
	SRR25897429_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

Transcriptional alterations of virulence-associated genes in extended spectrum beta-lactamase (ESBL)-producing uropathogenic Escherichia coli during morphologic transitions induced by ineffective antibiotics

Project description:The present study examines changes in global gene expression patterns and in virulence factor-associated genes in an extended spectrum beta-lactamase (ESBL)-producing UPEC (ESBL019) during the morphologic transitions induced by an ineffective antibiotic and in the presence of human primary bladder epithelial cells. The morphological shifts induced by ineffective antibiotics are associated with significant transcriptional virulence alterations in ESBL-producing UPEC, which may affect survival and persistence in the urinary tract.

2017-06-06 | GSE99661 | GEO

Project description:Within-host genetic diversity of extended spectrum beta-lactamase (ESBL)-producing Enterobacterales

| PRJNA910977 | ENA

ABRES dairy cattle

Project description:Dynamics of faecal shedding of Extended Spectrum beta-Lactamase or AmpC-producing Escherichia coli on dairy farms

| PRJEB30024 | ENA

Extended-Spectrum Beta-Lactamase(ESBL)-producing E.coli from raw meats in Singapore markets

Project description:Extended-Spectrum Beta-Lactamase(ESBL)-producing E.coli from raw meats in Singapore markets

| PRJEB34067 | ENA

RNAseq transcriptome analysis of K. pneumoniae MS6671 and E. coli MS8345 treated with PBT2

Project description:The emergence of colistin resistance in carbapenem-resistant and extended-spectrum ß-lactamase (ESBL)-producing bacteria is a significant threat to human health, and new treatment strategies are urgently required. Here we investigated the ability of the safe-for-human use ionophore PBT2 to restore antibiotic sensitivity in several polymyxin-resistant, ESBL-producing, carbapenem resistant Gram-negative human pathogens. PBT2 was observed to resensitize Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa to last-resort polymyxin class antibiotics, including a ‘next generation’ polymyxin derivative, FADDI-287. To gain additional insight into the potential mechanism of action of PBT2, we analyzed the transcriptome of K. pneumoniae and E. coli in the presence of sub-inhibitory concentrations of PBT2. Treatment with PBT2 was associated with multiple stress responses in both K. pneumoniae and E. coli. Significant changes in the transcription of transition metal ion homeostasis genes were observed in both strains.

2019-06-13 | GSE132637 | GEO

ESBL producing E. coli from horses

Project description:Fecal carriage of Extended Spectrum beta-Lactamase (ESBL)/ AmpC-producing Escherichia coli in horses

| PRJEB34847 | ENA

Extended Spectrum Beta-Lactamase-producing Enterobacteriaceae

Project description:Extended Spectrum Beta-Lactamase-producing Enterobacteriaceae Raw sequence reads

| PRJNA476828 | ENA

Project description:Evolution of extended-spectrum beta-lactamase-producing Escherichia coli

| PRJNA874473 | ENA

BeanSprouts_ESBL-Kp

Project description:Extended-Spectrum Beta-Lactamase producing Enterobacteriaceae (ESBL-E) isolated from bean sprouts in the Netherlands

| PRJEB25080 | ENA

RNAseq transcriptome analysis of K. pneumoniae MS6671 with PBT2 and colistin

Project description:The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum -lactamase (ESBL)-producing bacteria is a critical threat to human health, and new treatment strategies are urgently required. Here, we investigated the ability of the safe-for-human use ionophore PBT2 to restore antibiotic sensitivity in polymyxin-resistant, ESBL-producing, carbapenem-resistant Gram-negative human pathogens. PBT2 was observed to resensitize Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa to last-resort polymyxin class antibiotics, including the less-toxic next-generation polymyxin derivative, FADDI-287. We were unable to select for mutants resistant to PBT2 + FADDI-287 in polymyxin resistant E. coli containing a plasmid-borne mcr-1 gene or K. pneumoniae carrying a chromosomal mgrB mutation. Using a highly invasive K. pneumoniae strain engineered for polymyxin resistance through mgrB mutation, we successfully demonstrated the efficacy of PBT2 + FADDI-287 in vivo for the treatment of Gram-negative sepsis. These data present a new treatment modality to break antibiotic resistance in high priority polymyxin-resistant Gram-negative pathogens.

2020-07-01 | GSE153553 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data