Schistosoma mansoni
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA101203 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:RNA isolated from S. mansoni worms grown in C57BL/6 or RAG-/- mice at 21, 23, 25 and 27 days post-infection was hybridized to a S. mansoni custom microarray. Expression was compared to a reference pool containing equal amounts of RNA from each condition and time point assayed. Keywords: Time course with two growth conditions (wt and RAG-/- mice)
2007-06-28 | GSE8254 | GEO
Project description:Schistosoma mansoni Transcriptome or Gene expression
| PRJNA299129 | ENA
Project description:Schistosoma mansoni Transcriptome or Gene expression
| PRJNA247810 | ENA
Project description:Transcriptional profiling of TGF-beta treated Schistosoma mansoni adult worms vs. Non-treated Schistosoma mansoni adult worms
2012-02-20 | GSE27050 | GEO
Project description:Background Schistosomiasis is caused by parasitic blood flukes of the genus Schistosoma. Despite ongoing mass drug administration efforts, the disease remains a major public health burden in endemic regions. A better understanding of early host responses to schistosomiasis is critical for developing effective vaccines and therapeutics. Methods We conducted a longitudinal transcriptomic study of peripheral blood samples from 30 Schistosoma-naïve volunteers participating in two controlled human infection trials with male-or female-only S. mansoni cercariae. Blood was collected at six time points over 20 weeks post-infection. Whole-transcriptome RNA sequencing and integrative analyses, including differential gene expression, gene set enrichment, protein interaction networks, co-expression clustering, and immune module profiling, were employed to characterize temporal modulation of genes related to immune responses. Results Robust and highly time-dependent transcriptional responses were observed, peaking at Week 4 post-infection. Differential gene expression and pathway analyses revealed activation of immune responses, including type I and II interferon signaling, chemokine-mediated pathways, and antigen presentation. Notably, both Th1 and Th2 signatures were evident at Week 4. Key immune hubs included IFNG, TNF, and IL1B, along with transcriptional regulators such as STAT1 and IRF7. Blood transcription module analysis further highlighted transient activation of interferon and plasma cell-related responses. Conclusions This study provides a comprehensive transcriptional map of early host responses to S. mansoni infection in humans. The findings underscore the central role of interferon pathways, early mixed Th1/Th2 polarization, and inflammation-associated gene signatures in shaping host response to S. mansoni infection. These insights may inform the rational design of vaccines and biomarkers for schistosomiasis.
2025-12-16 | GSE313156 | GEO
Project description:Nitric oxide-dependent changes in Schistosoma mansoni gene expression
| PRJNA101391 | ENA
Project description:Transcriptional profiling using two subsequent developmental stages of Schistosoma mansoni (Egg vs. Miracidium; Cercaria vs. 7-days-old Schistosomulum; 7-days-old Schistosomulum vs. Adult worms
2011-04-30 | GSE27026 | GEO