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Radial glia promote microglial development through aVb8 -TGFb1 signaling [ATAC-seq]

ABSTRACT: Radial glia promote microglial development through aVb8 -TGFb1 signaling [ATAC-seq]

PROVIDER: PRJNA1012104 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25880447_1.fastq.gz	Fastqsanger.gz
	SRR25880447_2.fastq.gz	Fastqsanger.gz
	SRR25880448_1.fastq.gz	Fastqsanger.gz
	SRR25880448_2.fastq.gz	Fastqsanger.gz
	SRR25880449_1.fastq.gz	Fastqsanger.gz

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Radial glia promote microglial development through aVb8 -TGFb1 signaling

Project description:Radial glia promote microglial development through aVb8 -TGFb1 signaling

| PRJNA1012101 | ENA

Radial glia promote microglial development through aVb8 -TGFb1 signaling [ChIP-seq]

Project description:Radial glia promote microglial development through aVb8 -TGFb1 signaling [ChIP-seq]

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Radial glia promote microglial development through aVb8 -TGFb1 signaling [ChIP-seq]

Project description:In this study, we aimed to identify 1) The relevant Itgb8 expressing cell types that mediate microglial TGFb activation; 2) The developmental timing of Itgb8-mediated TGFb signaling in microglia; 3) The cellular source and identity of the TGFb ligand relevant for microglial development and homeostasis; 4) The relationship between developmentally disrupted microglia and disease associated microglia; and 5) The role of canonical (Smad-mediated) versus non-canonical TGFb signaling in microglia.

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Radial glia promote microglial development through aVb8 -TGFb1 signaling [ATAC-seq]

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Radial glia promote microglial development through aVb8 -TGFb1 signaling

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-02 | GSE242221 | GEO

Transcription profiling of mouse functionally distinct radial glial subsets

Project description:Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the molecular determinants specifying neurogenic radial glia differently from radial glia that mostly self-renew remain ill-defined. Here, we isolated two radial glial subsets that co-exist at mid-neurogenesis in the developing cerebral cortex and their immediate progeny. While one subset generates neurons directly, the other is largely non-neurogenic but also gives rise to Tbr2-positive basal precursors, thereby contributing indirectly to neurogenesis. Isolation of ; these distinct radial glia subtypes allowed determining interesting differences in their transcriptome. These transcriptomes were also strikingly different from the transcriptome of radial glia isolated at the end of neurogenesis. This analysis therefore identifies, for the first time, the lineage origin of basal progenitors and the molecular differences of this lineage in comparison to directly neurogenic and gliogenic radial glia. Experiment Overall Design: Comparison of radial glial subtypes

2008-06-18 | E-GEOD-8034 | biostudies-arrayexpress

Microglial gene expression after TGFb1 treatment in vitro

Project description:Microglial gene expression after TGFb1 treatment in vitro

| PRJNA475680 | ENA

Generation of cellular diversity through temporal patterning of radial glia during mouse corticogenesis II

Project description:Neural cell type diversity arises from both spatial and temporal patterning of neural stem cells. Although spatial patterning mechanisms have been extensively studied, temporal patterning mechanisms remain relatively unexplored. In this study, we addressed generation of diverse neural cell types through lineage progression of mouse cortical radial glia. The time series scRNA-seq and snATAC-seq of mouse cortical development revealed that radial glia temporally transitioned from neurogenesis to gliogenesis. During gliogenic stages, various cell types were generated simultaneously along multidirectional lineage trajectories. We established comprehensive molecular maps for cortical lineage commitment and cellular diversification. The transcriptome and epigenome of cortical radial glia exhibit temporal dynamics, as revealed by scRNA-seq and snATAC-seq. Lhx2, a transcription factor with temporal dynamic chromatin binding activities, was identified as a key regulator of the neurogenesis-to-gliogenesis transition. It maintains neurogenic competence by establishing the active epigenetic state of its target genes.

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Generation of cellular diversity through temporal patterning of radial glia during mouse corticogenesis I

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Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain

Project description:Zebrafish display widespread and pronounced adult neurogenesis, which is fundamental for their regeneration capability after central nervous system injury. However, the cellular identity and the biological properties of adult newborn neurons are elusive for most brain areas. Here, we used short-term lineage tracing of radial glia progeny to prospectively isolate newborn neurons from the her4.1+ radial glia lineage in the homeostatic adult forebrain. Transcriptome analysis of radial glia, newborn neurons and mature neurons using single cell sequencing identified distinct transcriptional profiles including novel markers for each population. Specifically, we detected 2 separate newborn neuron types, which showed diversity of cell fate commitment and location. Further analyses showed homology of these cell types to neurogenic cells in the mammalian brain, identified neurogenic commitment in proliferating radial glia and indicated that glutamatergic projection neurons fate are generated in the adult zebrafish telecephalon. Thus, we prospectively isolated adult newborn neurons from the adult zebrafish forebrain, identified markers for newborn and mature neurons in the adult brain, revealed intrinsic heterogeneity among adult newborn neurons and their homology to mammalian adult neurogenic cell types.

2019-11-27 | GSE137525 | GEO

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