Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: FC-ocular mucosa

PROVIDER: PRJNA1012574 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25896131_1.fastq.gz	Fastqsanger.gz
	SRR25896131_2.fastq.gz	Fastqsanger.gz
	SRR25896132_1.fastq.gz	Fastqsanger.gz
	SRR25896132_2.fastq.gz	Fastqsanger.gz
	SRR25896133_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Gene expression profiling of holoclones from limbus, conjunctiva and oral mucosa

Project description:The research of a specific oral mucosa epithelial marker was performed by microarray analysis of holoclones derived from cornea, conjunctiva and oral mucosa tissues. The results identified SOX2 and PAX6 as positive and negative markers to assess the presence (or absence) of oral epithelium onto the ocular surface.

2025-03-10 | GSE198408 | GEO

Quantitative proteomic analysis of vitreous from patients with proliferative diabetic retinopathy (PDR) using SWATH-MS

Project description:Pathological neovascularization and vascular leakage are central drivers of many sight- threatening diseases. While strategies targeting vascular endothelial growth factor (VEGF) have transformed clinical outcomes, a substantial proportion of patients do not benefit from the treatment, partially attributed to compensatory activation of alternative angiogenic pathways. Two independent vitreous proteomics studies in patients with proliferative diabetic retinopathy (PDR) revealed a significant reduction in the level of Frizzled-related Protein (FRZB), a finding mirrored in preclinical models of ocular angiogenesis. Loss of Frzb in mice exacerbated ocular angiogenesis, while therapeutic delivery of Fc-FRZB recombination protein or its functional domain netrin-related motif (NTR) potently suppressed and reversed ocular angiogenesis across various preclinical models. Notably, Fc-NTR synergized with Aflibercept, suggesting its potential as a combination therapy. Mechanistically, FRZB doesn’t modulate Wnt signalling in retinal microvascular endothelial cells. Instead, it binds directly to Caveolin-1 (CAV1), inhibits its phosphorylation, promotes surface retention of the TGFβ type I receptor ALK5, and ultimately leads to cytoplasmic accumulation of phosphorylated Smad2/3. Intriguingly, retinal endothelial cells expressing a phosphomimetic CAV1 mutant (Y42D) at a previously uncharacterized site, Tyr42, were resistant to FRZB’s anti-angiogenic effects, establishing a novel CAV1–TGFβ signalling axis as the molecular basis of FRZB’s action. Collectively, these findings define FRZB as a novel suppressor of ocular angiogenesis, uncover a previously unknown mechanism of TGFβ regulation, and establish Fc-NTR as a promising therapeutic candidate for treating ocular angiogenic diseases.

2026-03-13 | PXD073005 | Pride

Phospho-proteomics study on FRZB-treated human retinal microvascular endothelial cells (HRECs)

2026-03-13 | PXD073342 | Pride

Genome-wide maps of histone lactylation in ocular melanoma by CUT&Tag

Project description:To investigate the function of histone lactylation in ocular melanoma, we analyzed histone lactylation enrichment level in ocular melanoma by CUT&Tag.

2023-09-04 | GSE242018 | GEO

Genome-wide maps of histone lactylation in ocular melanoma by CHIP-seq

Project description:To investigate the function of histone lactylation in ocular melanoma, we analyzed histone lactylation enrichment level in ocular melanoma by CHIP-seq.

2023-09-04 | GSE242013 | GEO

Variant-specific disruption to Notch signaling in PAX6 microphthalmia and aniridia patient-derived hiPSC optic vesicles [ATAC-Seq]

Project description:The homeobox-containing transcription factor PAX6 is a key regulator of eye development. Pathogenic heterozygous PAX6 variants lead to variable ocular phenotypes. Missense variants are often associated with milder ocular conditions, although variants in the DNA-binding paired domain which alter target binding lead to severe ocular phenotypes including bilateral microphthalmia, similar to SOX2 anophthalmia syndrome. However, the variant-specific pathway disruption resulting in phenotypic heterogeneity is not well understood.

2025-05-22 | GSE288050 | GEO

Project description:Sequencing of microglia treated with Fc or STREM2-Fc

| PRJNA986962 | ENA

Project description:Sequencing of microglia treated with Fc or STREM2-Fc

| PRJNA980945 | ENA

Dectin-1 Fc and Dectin-2 Fc

Project description:Dectin-1 Fc and Dectin-2 Fc Raw sequence reads

| PRJNA1146185 | ENA

Genome wide profiling of the RNAPII, γH2AX, H3K4Me1, H3K4M2 and H3K4Me3 in MLL2 F/F and FC/FC MEF cells

Project description:We investigated the RNAPII and γH2AX occupancy genome wide by ChIP-Seq in MLL2 F/F and FC/FC80 MEF cells. We found that a week after MLL2 excision (FC/FC cells), a group of genes present higher levels of γH2AX and RNAPII near the TSS, as compared to the control (F/F cells). H3K4Me1, H3K4M2 and H3K4Me3 levels near the TSS were also studied.

2016-04-13 | GSE73124 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data