Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide DNA methylation profiles in post-mortem autistic brains

ABSTRACT: Genome-wide DNA methylation profiles in post-mortem autistic brains

PROVIDER: PRJNA1013408 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genome-wide DNA methylation profiles in post-mortem autistic brains

Project description:Previous studies indicate that autism has a strong genetic component; however, the underlying genetic mechanisms remain unclear. Recently, it was reported that genetic heritability is lower than previously estimated, and that environmental factors have a greater influence on the development of autism spectrum disorder (ASD). Epigenetic processes such as DNA methylation are considered to be at the interface of genetic and environmental factors. Additionally, two well-characterized epigenetic processes, parental imprinting and X chromosome inactivation, are involved in several conditions that mimic autism spectrum disorders, such as Rett and Fragile-X syndromes, suggesting that epigenetic processes may play an important role in the pathophysiology of autism. We investigated genome-wide DNA methylation profiles in post-mortem brain tissue from individuals with autism using the Infinium HumanMethylation450 BeadChip (Illumina), which includes CpG sites of intragenic and intergenic regions.

2025-07-16 | GSE242427 | GEO

Genome-wide methylation profiles of post-mortem tissue samples (human)

Project description:Genome-wide methylation profiles of post-mortem tissue samples (human)

| PRJNA1026588 | ENA

DNA methylation in neurons from post-mortem brains in schizophrenia and bipolar disorder

Project description:DNA methylation in neurons from post-mortem brains in schizophrenia and bipolar disorder

| PRJNA448067 | ENA

DNA methylation analysis of the autistic brain reveals dysregulated biological pathways

Project description:Genome wide DNA methylation profiling of post-mortem human brain samples from both autistic individuals and nonautistic individuals. Samples of the frontal cortex (BA10) and cingulate cortex (BA24) were examined from each individual.

2014-09-03 | GSE53924 | GEO

Genome-wide methylation profiles of post-mortem tissue samples (human) 3

Project description:In this study, 60 post-mortem tissue samples comprising four tissue types (dermis, epidermis, and muscle) were collected from autopsies of 20 Koreans aged 18 to 78. 250 ng of genomic DNA (gDNA) was employed to generate DNA methylation profiles utilizing the Illumina Infinium MethylationEPIC BeadChip array (Illumina, San Diego, CA, USA) at Macrogen Inc. (Macrogen, Seoul, Korea).

2023-10-22 | GSE244995 | GEO

Genome-wide methylation profiles of post-mortem tissue samples (human) 2

Project description:In this study, 60 post-mortem tissue samples comprising four tissue types (kidney, liver, and lung) were collected from autopsies of 20 Koreans aged 18 to 78. 250 ng of genomic DNA (gDNA) was employed to generate DNA methylation profiles utilizing the Illumina Infinium MethylationEPIC BeadChip array (Illumina, San Diego, CA, USA) at Macrogen Inc. (Macrogen, Seoul, Korea).

2023-10-22 | GSE244994 | GEO

Genome-wide methylation profiles of post-mortem tissue samples (human) 1

Project description:In this study, 60 post-mortem tissue samples comprising three tissue types (blood, brain, and heart) were collected from autopsies of 20 Koreans aged 18 to 78. 250 ng of genomic DNA (gDNA) was employed to generate DNA methylation profiles utilizing the Illumina Infinium MethylationEPIC BeadChip array (Illumina, San Diego, CA, USA) at Macrogen Inc. (Macrogen, Seoul, Korea).

2023-10-22 | GSE244993 | GEO

DNA methylation in neurons from post-mortem brains in schizophrenia and bipolar disorder (Methylation)

Project description:DNA methylation in neurons from post-mortem brains in schizophrenia and bipolar disorder (Methylation)

| PRJNA445175 | ENA

Genome-wide methylation profiles of post-mortem tissue samples (human) 1

Project description:Genome-wide methylation profiles of post-mortem tissue samples (human) 1

| PRJNA1026589 | ENA

Genome-wide methylation profiles of post-mortem tissue samples (human) 2

Project description:Genome-wide methylation profiles of post-mortem tissue samples (human) 2

| PRJNA1026590 | ENA