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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [scRNA-seq]

ABSTRACT: SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [scRNA-seq]

PROVIDER: PRJNA1013571 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR25933506_1.fastq.gz	Fastqsanger.gz
	SRR25933506_2.fastq.gz	Fastqsanger.gz
	SRR25933507_1.fastq.gz	Fastqsanger.gz
	SRR25933507_2.fastq.gz	Fastqsanger.gz
	SRR25933508_1.fastq.gz	Fastqsanger.gz

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [RNA-seq]

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [CUT&RUN]

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [ChIP-seq]

Project description:SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [ChIP-seq]

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [RNA-seq]

Project description:RNA-seq was used to compare the effect of SUMOylation inhibition, and Etv1 knockdown on Ube2iF/F cell line transcriptiome. 5xKR or 5xKR-S1 was expressed to examine differential phenotypic transcriptiome changes.

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [ChIP-seq]

Project description:Sumoylation alters the transcriptional activity of many of the transcription factors known to regulate CSCs/TICs and epithelial-mesenchymal transition (EMT). To identify transcription factor involved in the growth effects mediated by SUMO inhibition, Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) was used to evaluate genomic occupancy by SUMO1 and Etv1.

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [CUT&RUN]

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SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-16 | GSE242487 | GEO

SUMOylated Etv1 establishes tumor-initiating cells during mammary oncogenesis [scRNA-seq]

Project description:scRNA-seq was used to compare the cell populations and transcriptiome in 6-week-old and 10-week-old FVB, MMTV-NIC, MMTV-NIC-Ube2ifl/fl mice

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ETV1 knockdown in GIST cell lines

Project description:ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown.

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