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DNA Methylation-Based High-Resolution Mapping of Long-Distance Chromosomal Interactions in Nucleosome-Depleted Regions (HiC)

ABSTRACT: DNA Methylation-Based High-Resolution Mapping of Long-Distance Chromosomal Interactions in Nucleosome-Depleted Regions (HiC)

PROVIDER: PRJNA1013711 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25918796_1.fastq.gz	Fastqsanger.gz
	SRR25918796_2.fastq.gz	Fastqsanger.gz
	SRR25918797_1.fastq.gz	Fastqsanger.gz
	SRR25918797_2.fastq.gz	Fastqsanger.gz
	SRR27548905_1.fastq.gz	Fastqsanger.gz

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DNA Methylation-Based High-Resolution Mapping of Long-Distance Chromosomal Interactions in Nucleosome-Depleted Regions

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DNA Methylation-Based High-Resolution Mapping of Long-Distance Chromosomal Interactions in Nucleosome-Depleted Regions (HiC)

Project description:Here, we present Methyltransferase Targeting-based chromosome Architecture Capture (MTAC), a method that maps the contacts between a target site (viewpoint) and the rest of the genome with high resolution and sensitivity. By targeting M.CviPI DNA methyltransferase to the viewpoint and by detecting differentially methylated regions, MTAC detects hundreds of intra- and inter-chromosomal interactions in the budding yeast genome that cannot be captured by 4C, Hi-C, or Micro-C.

2023-09-05 | GSE242396 | GEO