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Tumor-intrinsic P2RY6 signaling promotes prostaglandin E2 production to suppress anti-tumor immunity [ATAC]

ABSTRACT: Tumor-intrinsic P2RY6 signaling promotes prostaglandin E2 production to suppress anti-tumor immunity [ATAC]

PROVIDER: PRJNA1015542 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26037659_1.fastq.gz	Fastqsanger.gz
	SRR26037659_2.fastq.gz	Fastqsanger.gz
	SRR26037660_1.fastq.gz	Fastqsanger.gz
	SRR26037660_2.fastq.gz	Fastqsanger.gz
	SRR26037661_1.fastq.gz	Fastqsanger.gz

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Tumor-intrinsic P2RY6 signaling promotes prostaglandin E2 production to suppress anti-tumor immunity [ATAC]

Project description:Our RNAseq results showed that P2RY6 induced the expression of Ptgs1 and Ptgs2 in MC38 cells. To confirm whether P2RY6 increases the opening of cis-regulatory elements to promote Ptgs1/2 transcription, we performed Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) to determain the chromatin accessibility across the genome in MC38 cells with or without P2RY6 expression.

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