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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma

ABSTRACT: METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma

PROVIDER: PRJNA1016411 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25915900_1.fastq.gz	Fastqsanger.gz
	SRR25915900_2.fastq.gz	Fastqsanger.gz
	SRR25915901_1.fastq.gz	Fastqsanger.gz
	SRR25915901_2.fastq.gz	Fastqsanger.gz
	SRR25915902_1.fastq.gz	Fastqsanger.gz

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [DNAme]

Project description:Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via DNA methylation and post-translational modifications of histone marks.

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [RNAseq]

Project description:METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [RNAseq]

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [scRNAseq]

Project description:METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [scRNAseq]

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [DNAme]

Project description:METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [DNAme]

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]

Project description:METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]

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METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma

Project description:This SuperSeries is composed of the SubSeries listed below.

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Lineage specification in glioblastoma is regulated by METTL7B.

Project description:Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineage specification in glioblastoma, with an impact on both tumor size and invasiveness. Single-cell transcriptomic analysis of these tumors and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B reveal a regulatory role for the gene in the neural stem cell-to-astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via post-translational modifications of histone marks.

| S-EPMC11220825 | biostudies-literature

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