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Hansenia weberbaueriana

ABSTRACT: Genome and transcriptome sequencing data of Notopterygium incisum

PROVIDER: PRJNA1017385 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR26074569_1.fastq.gz	Fastqsanger.gz
	SRR26074569_2.fastq.gz	Fastqsanger.gz
	SRR26074570_1.fastq.gz	Fastqsanger.gz
	SRR26074570_2.fastq.gz	Fastqsanger.gz

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Hansenia weberbaueriana

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Project description:In order to more accurately discover the cause of drug resistance in tumor treatment, and to provide a new basis for precise treatment. Therefore, based on the umbrella theory of precision medicine, we carried out this single-center, prospective, and observational study to include patients with liver metastases from colorectal cancer. By combining genome, transcriptome, and proteomic sequencing data, we established a basis for colorectal cancer liver Transfer the multi-omics data of the sample, describe the reason for the resistance of the first-line treatment, and search for new therapeutic targets.

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Project description:Transcriptomic analysis of the molecular mechanism of seed dormancy release in Notopterygium incisum

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<i>Hansenia weberbaueriana</i> (Fedde ex H.Wolff) Pimenov & Kljuykov Extract Suppresses Proliferation of HepG2 Cells via the PTEN-PI3K-AKT Pathway Uncovered by Integrating Network Pharmacology and <i>Iin Vitro</i> Experiments.

Project description:Previous studies have shown that Hansenia weberbaueriana (Fedde ex H.Wolff) Pimenov & Kljuykov extracts (HWEs) have antitumor activity, but their mechanism in vitro is still unclear. In this study, we first combined network pharmacology with experimental evaluation and applied a comprehensive strategy to explore and prove the therapeutic potential and potential mechanism of HWE. The mRNA expression profiles of PTEN, PIK3A, and AKT1 are from the Cancer Cell Line Encyclopedia (CCLE) of the Broad Institute. Our results showed that HWE has a good inhibition on HepG2 cells, and a slight inhibition on other cells. The results of the CCLE database showed that PTEN/PIK3A/AKT1 mRNA expression was up-regulated in HepG2 cells. Through further study, it was found that HWE increased the release of LDH, induced early and late apoptosis, and increased ROS levels in HepG2 cells. Western blot showed that HWE regulates the expression of mitochondrial apoptosis-related proteins. Meanwhile, the expression of PTEN was increased, and the expression of phosphorylated PI3K and Akt was down-regulated after HWE treatment. Our results show that HWE promotes HepG2 cell apoptosis via the PTEN-PI3K-Akt signaling pathway. This study is the first to report the potential role of HWE in the treatment of liver cancer.

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Analysis of Naja naja snake venom

Project description:GelC-MS analysis of Naja naja snake venom that goes alongside a genome sequencing and transcriptome analysis of the Indian cobra.

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Project description:Comparative transcriptome analysis revealed adaptive evolution of Notopterygium incisum and N. franchetii, the two high-alpine herbal species endemic to China

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