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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

ABSTRACT: PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

PROVIDER: PRJNA1017840 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26071362_1.fastq.gz	Fastqsanger.gz
	SRR26071363_1.fastq.gz	Fastqsanger.gz
	SRR26071364_1.fastq.gz	Fastqsanger.gz
	SRR26071365_1.fastq.gz	Fastqsanger.gz
	SRR26071366_1.fastq.gz	Fastqsanger.gz

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

Project description:Sarcopenia, characterized by the loss of muscle mass, strength, and function, predisposes adverse outcomes and its mechanism is waiting to reveal. Here, we report decrease of PRR14, a nuclear protein, in skeletal muscle results in sarcopenia. Genetically, genome-wide association studies (GWAS) identified multiple single nucleotide polymorphisms (SNPs) in PRR14 locus associated with body mass index (BMI) and total body lean mass, which indicated its association with sarcopenia; Specific knockout of skeletal muscle Prr14 in mice confirmed the causal effect; Biochemical analysis and high-throughput sequencing, including both transcriptome and approaches for the study of the epigenome (CUT&Tag sequencing and ATAC sequencing), revealed that Prr14 was required for myofiber homeostasis in skeletal muscle: Prr14 loss altered chromatin structure and reduced Mef2c activity, which in combination resulted in failure of maintaining myofiber identity and therefore sarcopenia. Our findings demonstrate that PRR14 orchestrates critical epigenetic changes and transcription factor activity to maintain myofiber identity, thereby providing novel therapeutic avenues for skeletal muscle pathologies associated with dysregulation of these mechanisms.

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

Project description:PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

Project description:PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

Project description:PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

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Project description:PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

Project description:the expression of TF MEF2C is decreased in skeletal muscle of PRR14-KO mice,which displays sarcopenia phenotype. Meanwhile, increasing MEF2C's expression in skeletal muscle lessens the phenotype.

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MEF2C chip in the skeletal muscle of PRR14-KO mice

Project description:the expression and splice forms are regulated in the skeletal muscle of PRR14-KO mice, to explore the underlying mechanism of MEF2C-mediated PRR14's function in skeletal muscle, the chip assay was performed

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PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

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2024-12-23 | GSE243334 | GEO