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Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome

ABSTRACT: Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome

PROVIDER: PRJNA1018259 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26083300_1.fastq.gz	Fastqsanger.gz
	SRR26083300_2.fastq.gz	Fastqsanger.gz
	SRR26083301_1.fastq.gz	Fastqsanger.gz
	SRR26083301_2.fastq.gz	Fastqsanger.gz
	SRR26083302_1.fastq.gz	Fastqsanger.gz

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Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome

Project description:Multisensory Gamma Stimulation (MGS) has previously been linked with improved cognitive performance in mouse models and patients with Alzheimer´s Disease (AD). In this study, we aimed to investigate the effects of chronic exposure to MGS in Ts65Dn mice, a mouse model of Down Syndrome (DS). For three weeks, mice were exposed daily to one hour of multisensory audiovisual stimulation or, as a control, one hour of ambient light and sound. Mice receiving MGS showed improved object recognition and spatial working memory. To gain mechanistic insight into how MGS improves cognitive function in Ts65Dn mice, we conducted single-nuclei RNA-seq (snRNA-seq) of hippocampal samples from control and treated mice. We found upregulation of genes related to synaptic organization and downregulation of genes related to aging and AD. Moreover, we detected upregulation of neurogenesis-related genes in the dentate gyrus. We validated these observations by demonstrating increased adult neurogenesis following MGS treatment. A potential mechanism underlying this MGS-mediated increase in adult neurogenesis is increased mitochondrial fusion. Together, our data indicate that MGS can ameliorate cognitive impairment in DS mice through modulation of conserved gene regulatory signatures and enhanced neurogenesis in hippocampal regions. These findings suggest that multisensory 40 Hz stimulation may have potential as a therapeutic approach to boost cognitive performance in individuals with Down Syndrome.

2025-04-25 | GSE243390 | GEO

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

Project description:The glymphatic movement of fluid through the brain powerfully clears metabolic waste. We observed multisensory 40 Hz stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer’s disease, which was associated with increased aquaporin-4 polarization along astrocytic endfeet, dilated meningeal lymphatic vessels, and amyloid accumulation in cervical lymph nodes. Inhibiting glymphatic clearance abolished the removal of amyloid by multisensory 40 Hz stimulation. Using chemogenetic manipulation and a genetically encoded sensor for neuropeptide signaling, we found VIP+ interneurons facilitate glymphatic clearance by regulating arterial pulsatility. Our findings establish novel mechanisms to recruit the glymphatic system to remove brain amyloid.

2023-12-23 | GSE249644 | GEO

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

Project description:Multisensory gamma stimulation promotes glymphatic clearance of amyloid

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Reduced adult neurogenesis and neuronal abnormalities in the hippocampus underlie cognitive deficiency following prenatal administration of the anti-epileptic drug valproic acid

Project description:Prenatal exposure to valproic acid, an established anti-epileptic drug, has been reported to impair postnatal cognitive function of children from epileptic mothers. Nevertheless, its pathology and proper treatment to minimize the effects remain unknown. In mice, we found that the postnatal cognitive function impairment was mainly caused by a reduction of adult neurogenesis and abnormal neuronal features in the hippocampus, which could be ameliorated by voluntary running. Pregnant mice received an oral administration of methylcellulose (MC), valproic acid (VPA) or valpromide (VPM) once a day on three consecutive embryonic days (E) 12.5, E13.5, and E14.5 and were sampled 3hr after the last administration (E14.5), at E18.5, and at 12 weeks of age.

2015-12-08 | E-GEOD-42904 | biostudies-arrayexpress

Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice

Project description:Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice

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Multisensory integration predated land plant colonization

Project description:Land plant colonization was a pivotal event in the evolution of photosynthetic eukaryotes. The transition from aquatic to terrestrial environments required complex multisensory systems that enabled plants to perceive and integrate a broader range of environmental cues, such as light intensity and temperature. However, it remains unclear whether this ability was a pre-adaptation or an innovation during early plant terrestrialization. Here, we show that the aquatic streptophyte ancestor of land plants could integrate light and temperature through a complex regulatory network. A conserved regulatory nexus, comprising phytochromes and transcription factors, was active in the last common ancestor of land plants, allowing the first terrestrial colonizers to adapt and flourish on the harsh terrestrial surface of our planet. Thus, we propose that the multisensory integration that enables extant plants to achieve perceptual disambiguation and fine-tune growth in various ecological niches was a pre-adaptation encoded in the genomes of ancestral land plants.

2026-04-22 | GSE284748 | GEO

Multisensory integration predated land plant colonization

Project description:Multisensory integration predated land plant colonization

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