Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rational cell fate engineering through chromatin dynamics [ATAC-Seq]

ABSTRACT: Rational cell fate engineering through chromatin dynamics [ATAC-Seq]

PROVIDER: PRJNA1018833 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26106200_1.fastq.gz	Fastqsanger.gz
	SRR26106200_2.fastq.gz	Fastqsanger.gz
	SRR26106201_1.fastq.gz	Fastqsanger.gz
	SRR26106201_2.fastq.gz	Fastqsanger.gz
	SRR26106202_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Rational cell fate engineering through chromatin dynamics

Project description:Rational cell fate engineering through chromatin dynamics

| PRJNA1018834 | ENA

Rational cell fate engineering through chromatin dynamics [RNA-Seq]

Project description:Rational cell fate engineering through chromatin dynamics [RNA-Seq]

| PRJNA1018838 | ENA

Rational cell fate engineering through chromatin dynamics [CUT&TAG]

Project description:Rational cell fate engineering through chromatin dynamics [CUT&TAG]

| PRJNA1018837 | ENA

Rational cell fate engineering through chromatin dynamics [RNA-Seq II]

Project description:Rational cell fate engineering through chromatin dynamics [RNA-Seq II]

| PRJNA1098230 | ENA

Rational cell fate engineering through chromatin dynamics [CUT&TAG II]

Project description:Rational cell fate engineering through chromatin dynamics [CUT&TAG II]

| PRJNA1098231 | ENA

Rational cell fate engineering through chromatin dynamics [ATAC-Seq]

Project description:Mechanism controlling cell fate remains elusive. Chromatin remodeling complex interacts with transcription factors to colocalize across the genome and regulate region-specific epigenetic environment. Here, we propose an engineering approach for controlling cell fate through chromatin closing and opening. We utilize chromatin remodeling complex, BAF, known to activate gene expression by opening chromatin loci. By grafting BAF interacting motifs onto Nanog, we show that engineering factors could promote somatic cell reprogramming with Oct4. Furthermore, mutation on the interacting motifs render iPSC generation. The syntactic factors facilitate cell fate transition by recruiting BAF complex to modulate chromatin accessibility and reorganize cell state specific enhancers. Our findings reveal alternative methods to control cell fate by manipulating chromatin accessibility.

2024-06-24 | GSE243513 | GEO