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Modeling pre-implantation development using totipotent blastomere-like stem cells [bulk RNA-seq]

ABSTRACT: Modeling pre-implantation development using totipotent blastomere-like stem cells [bulk RNA-seq]

PROVIDER: PRJNA1020573 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26158000_1.fastq.gz	Fastqsanger.gz
	SRR26158000_2.fastq.gz	Fastqsanger.gz
	SRR26158001_1.fastq.gz	Fastqsanger.gz
	SRR26158001_2.fastq.gz	Fastqsanger.gz
	SRR26158002_1.fastq.gz	Fastqsanger.gz

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Project description:During development, totipotent blastomeres initiate the first cell fate decision to generate inner cell mass and trophectoderm. The trophectoderm forms the placenta mediating fetal-maternal communications, while placental deficiencies cause infertility and pregnancy disorders in humans. However, in vitro systems remodeling the step-wise placental development, particularly encompassing the pre-implantation phase, are still unavailable. Here, using mouse totipotent blastomere-like cells (TBLCs), we successfully realize inducing and long-term maintaining trophectoderm-like stem cells (TELSCs), and further generating placental trophoblast organoids. Interestingly, an intermediate morula trophectoderm-like cells (TELCs) were transiently induced from TBLCs, and quickly converted into TELSCs assembling blastocyst trophectoderm. In 3D culturing condition, TELSCs can form rosette-like structures at peri-implantation period, to eventually generate trophoblast organoids, in which trophoblast progenitors/giant cells, spongiotrophoblasts and syncytiotrophoblasts were all identified at the single-cell level. Transcriptomic and epigenomic analyses enable tracing the step-by-step transition from TBLCs to mature trophoblast lineages. Thus, this study provides a comprehensive differentiation system to understand and investigate placental development.

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