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Single cell RNA-sequencing analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) in a xenograft model of lung adenocarcinoma

ABSTRACT: single cell RNA-sequencing analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) in a xenograft model of lung adenocarcinoma

PROVIDER: PRJNA1021137 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26186000_1.fastq.gz	Fastqsanger.gz
	SRR26186000_2.fastq.gz	Fastqsanger.gz
	SRR26186001_1.fastq.gz	Fastqsanger.gz
	SRR26186001_2.fastq.gz	Fastqsanger.gz
	SRR26186002_1.fastq.gz	Fastqsanger.gz

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single cell RNA-sequencing analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) in a xenograft model of lung adenocarcinoma

Project description:We have observed that the inactivation of SUV39H1 enhances 41BBz-CAR T cell long-term persistence, providing protection against tumor relapses and rechallenges in a xenograft mouse model of lung adenocarcinoma. The purpuse of this study is to investigate the transcriptomic differences of lung-infiltrating SUV39H1 knock-out versus mock 41BBz-CAR T cells by single cell RNA sequencing at days 8 and 28 after CAR T cell infusion.

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