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Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

ABSTRACT: Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

PROVIDER: PRJNA1021189 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26187000_1.fastq.gz	Fastqsanger.gz
	SRR26187000_2.fastq.gz	Fastqsanger.gz
	SRR26187001_1.fastq.gz	Fastqsanger.gz
	SRR26187001_2.fastq.gz	Fastqsanger.gz
	SRR26187002_1.fastq.gz	Fastqsanger.gz

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Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance [scRNA-seq]

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Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance.

Project description:Tissue regeneration is a complex process involving large changes in cell proliferation, fate determination, and differentiation. Mitochondrial dynamics and metabolism play a crucial role in development and wound repair, but their function in large-scale regeneration remains poorly understood. Planarians offer an excellent model to investigate this process due to their remarkable regenerative abilities. In this study, we examine mitochondrial dynamics during planarian regeneration. We find that knockdown of the mitochondrial fusion gene, opa1, impairs both tissue regeneration and stem cell pluripotency. Interestingly, the regeneration defects caused by opa1 knockdown are rescued by simultaneous knockdown of the mitochondrial fission gene, drp1, which partially restores mitochondrial dynamics. Furthermore, we discover that Mitolow stem cells exhibit an enrichment of pluripotency due to their fate choices at earlier stages. Transcriptomic analysis reveals the delicate mitonuclear balance in metabolism and mitochondrial proteins in regeneration, controlled by mitochondrial dynamics. These findings highlight the importance of maintaining mitochondrial dynamics in large-scale tissue regeneration and suggest the potential for manipulating these dynamics to enhance stem cell functionality and regenerative processes.

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The human mitochondrial translatome promotes mitonuclear balance

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Mitochondrial Dynamics Govern Whole-body Regeneration Through Stem Cell Pluripotency and Mitonuclear Balance

Project description:This SuperSeries is composed of the SubSeries listed below.

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