Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

ABSTRACT: Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

PROVIDER: PRJNA1021254 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26186079.fastq.gz	Fastqsanger.gz
	SRR26186080.fastq.gz	Fastqsanger.gz
	SRR26186081.fastq.gz	Fastqsanger.gz
	SRR26186082.fastq.gz	Fastqsanger.gz
	SRR26186093.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 7

Similar Datasets

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single nucleus RNA-seq on human ONB tumor]

Project description:The olfactory epithelium relies on active neuron regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare, aggressive tumor of unclear origins. Here, we establish a new, highly-penetrant, genetically-engineered mouse model of ONB with alterations in Rb1/Trp53/Myc that exhibit a NEUROD1+ immature neuronal state. ASCL1 loss leads to emergence of non-neuronal histopathologies, including a POU2F3+ microvillar-like state. We find ONB tumor heterogeneity to recapitulate developmental states of multipotent globose basal cells (GBCs), which our data demonstrate is a cell of origin for ONB. Similar to small cell lung cancer (SCLC), mouse and human ONB exhibit: mutually exclusive ASCL1, NEUROD1, and POU2F3- like states, an immune-cold tumor microenvironment, intratumoral subtype heterogeneity comprising neuronal and non-neuronal lineages, and subtype plasticity—as evidenced by barcode-based lineage tracing and single-cell transcriptomics. Collectively, our findings highlight conserved developmental trajectories between ONB and SCLC subtypes with significant implications for ONB classification and treatment.

2024-05-15 | GSE248746 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Spatial transcriptomics on de-identified human ONB samples]

2024-05-15 | GSE244117 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

2024-05-15 | GSE244122 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single nucleus RNA-seq on human ONB tumor]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single nucleus RNA-seq on human ONB tumor]

| PRJNA1045693 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Spatial transcriptomics on de-identified human ONB samples]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Spatial transcriptomics on de-identified human ONB samples]

| PRJNA1021255 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM and RPMA GBC-derived allograft tumors, CellTagged]

2024-05-15 | GSE244119 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

| PRJNA1021258 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM and RPMA GBC-derived allograft tumors, CellTagged]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM and RPMA GBC-derived allograft tumors, CellTagged]

| PRJNA1021257 | ENA

Epigenetic subtypes of neuroblastoma [neuroblastoma]

Project description:Epigenetic subtypes of neuroblastoma [neuroblastoma]

| PRJNA559905 | ENA

Transcriptomic profiling of the normal mammalian olfactory mucosa and olfactory neuroblastoma

Project description:Characterizing olfactory neuroblastoma with respect to normal olfactory mucosal tissue and cell types

2022-05-05 | GSE166612 | GEO