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Quantseq 3'mRNA-seq in Ctrl and TXNIP OE BMOL cells

ABSTRACT: Quantseq 3'mRNA-seq in Ctrl and TXNIP OE BMOL cells

PROVIDER: PRJNA1024418 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26287789.fastq.gz	Fastqsanger.gz
	SRR26287790.fastq.gz	Fastqsanger.gz
	SRR26287791.fastq.gz	Fastqsanger.gz
	SRR26287792.fastq.gz	Fastqsanger.gz
	SRR26287793.fastq.gz	Fastqsanger.gz

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Quantseq 3'mRNA-seq in Ctrl and TXNIP OE BMOL cells

Project description:RNA samples were collected from Ctrl and TXNIP OE BMOL cells. High-throughput sequencing was performed as single-end 75 sequencing using NextSeq 550.

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Quantseq 3'mRNA-seq in LESCs from WT and TXNIP-/- mice

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Wildtype (wt) mouse cone transcriptome change with Txnip treatment

Project description:Purpose: To identifiy mRNA changes in wt cone photoreceptors with Txnip overexpression treatment, which improved retinitis pigmentosa (RP) cone survival and visual acuity. Methods: two wt mouse strains, BALB/c and C57BL/6J were injected with AAV-Txnip or AAV-H2BGFP control subretinally at P0. Retinas were dissected out at P21 for BALB/c and P35 for C57BL/6J. 1,000 H2BGFP labeled cones per retina sample were FACS sorted out, and subject for RNA-sequencing. Results: only ~70 genes in P21 BALB/c and 1 genes in C57BL/6J were found differentially expressed with Txnip treatment. Only 1 genes (i.e. Txnip) were in commonly upregulated between the two lists. Conclusions: Txnip seems to be not changing RNA expression much in wt cones. Instead, its major function to rescue RP cones may lay in protein-protein interactions.

2021-03-15 | GSE168503 | GEO

Retinitis pigmentosa (RP) mouse cone transcriptom change with Txnip treatment

Project description:Purpose: To identifiy mRNA changes in retinitis pigmentosa (RP) cone photoreceptors with Txnip overexpression treatment, which improved RP cone survival and visual acuity. Methods: two RP mouse strains, rd1 and Rho-/-, were injected with AAV-Txnip or AAV-H2BGFP control subretinally at P0. Retinas were dissected out at P21 for rd1 and P90 for Rho-/-. 1,000 H2BGFP labeled cones per retina sample were FACS sorted out, and subject for RNA-sequencing. Results: >1,400 genes in P21 rd1 and >700 genes in Rho-/- were found differentially expressed with Txnip treatment. Conclusions: 25 genes are in common between P21 rd1 and P90 Rho-/- with Txnip treatment. On this list, notably, three mitochondrial Electron Transport Chain (ETC) genes were up-regulated.

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Secretome from TXNIP knockout human colorectal cell line (DLD1)

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TXNIP loss expands Myc transcriptome

Project description:To examine the generality of our finding where the gene expression profile of TXNIP knockout in MDA-MB-231 cells resembles of that Myc overexpression transcriptional program, our lab has generated TXNIP null HCC70 (HCC70:TKO) and MB135 (MB135:TKO) cells. We characterized the gene exrpession programs of these cells by RNA-seq.

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