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Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen).

ABSTRACT: Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen).

PROVIDER: PRJNA1025025 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26314877.fastq.gz	Fastqsanger.gz
	SRR26314878.fastq.gz	Fastqsanger.gz
	SRR26314879.fastq.gz	Fastqsanger.gz
	SRR26314880.fastq.gz	Fastqsanger.gz
	SRR26314881.fastq.gz	Fastqsanger.gz

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Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen).

Project description:Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen). Study described in manuscript "A non-inteferon role of STING in pulmonary hypertension". We used scRNAseq to analyze the difference in pulmonary cells and different gene expression across populations between wild type and STING-/- underwent pulmonary hypertension induction with chronic hypoxia.

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Expression data from 8-10 week old WT mice maintained in room air or exposed to hyperoxia (FiO2>95%) for 48 hrs

Project description:To detect sex-specific differences in gene expression in a model of hyperoxic lung injury in adult C56BL/6J mice. In this dataset, we include the expression data obtained from lungs from 8-10 week old male and female WT C57BL/6J mice exposed to hyperoxia for 48 hours amd room air controls.These data were used to determine differences in transcriptome between male and female mice after hyperoxia exposure 12 total samples were analyzed. We generated the following pairwise comparisons: 5 comparisons (M/F: male/female, A/O: air/oxygen): 1) M_O - M_A,  2) F_O - F_A, 3) M_O - F_O, 4) M_A - F_A, 5) (M_O - M_A) - (F_O - F_A). Genes with an FDR≤5% and a fold-change ≥1.4 were selected.

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Project description:Seven-day-old C57BL/6 mice and IL-19 knockout (KO) mice were subjected to 75% oxygen for 5 days to induce OIR. To explore the mechanism that caused by IL-19 on retinal neovascularization, Gene expressions among retinas of room air control mice, OIR wildtype mice, and OIR IL-19 knockout mice were measured by RNA-sequencing (RNA-seq).

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Project description:It is unclear why preterm birth increases risk of cardiovascular disease later in life. Studies in mice indicate excess oxygen used to treat preterm infants causes pulmonary hypertension, cardiac failure, and shortens lifespan. We previously reported neonatal hyperoxia causes pulmonary hypertension in aged mice as defined pathologically by pulmonary capillary rarefaction, dilation of pulmonary arterioles and veins, right ventricular hypertrophy, and reduced lifespan. Here, affymetrix gene arrays were used to identify early transcriptional changes in lungs of young adult mice exposed to room air or 100% oxygen between postnatal days 0-4.

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