Project description:A new haloalkaliphilic species of Wenzhouxiangella, strain AB-CW3 was isolated from a system of alkaline soda lakes in the Kulunda Steppe. Its complete, circular genome was assembled from combined nanopore and illumina sequencing and its proteome was determined for three different experimental conditions: growth on Staphylococcus cells, casein, or peptone. AB-CW3 is an aerobic bacterium feeding mainly on proteins and peptides.
Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Project description:In this study, we present the first representative complete Taphozous melanopogon mitochondrial genome from China. Its mitochondrial genome was assembled and annotated using MitoZ. The genome is a circular molecule of 16,566 bp in length, including 22 transfer RNA genes, 2 ribosomal RNA genes, 13 protein-coding genes, and a control region. Although maximum-likelihood and Bayesian inference phylogenetic trees indicate that the super family Emballonuridea forms a sister taxon with Noctilionidea instead of Vespertilionidea, mitochondrial genes provide only part of the phylogenetic information, and phylogenetic inferences utilizing nuclear genes are needed in future toward resolving phylogenetic relationship among Vespertilionidea, Noctilionidea, and Emballonuridea.