Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comprehensive analysis of differentially expressed microRNAs involved in diabetic trigeminal ganglion

ABSTRACT: Comprehensive analysis of differentially expressed microRNAs involved in diabetic trigeminal ganglion

PROVIDER: PRJNA1027341 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26372691.fastq.gz	Fastqsanger.gz
	SRR26372692.fastq.gz	Fastqsanger.gz
	SRR26372693.fastq.gz	Fastqsanger.gz
	SRR26372694.fastq.gz	Fastqsanger.gz
	SRR26372695.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Comprehensive analysis of differentially expressed microRNAs involved in diabetic trigeminal ganglion

Project description:Diabetic keratopathy(DK) is a common ocular complication of diabetes that seriously threatens diabetic patients' vision. Here, by sequencing of microRNAs (miRNAs) from diabetic and normal TG tissues, we aimed to uncover potential miRNAs involved in the pathogenesis of diabetic corneal neuropathy.

2023-10-18 | GSE245193 | GEO

The transcriptional landscape of the developing chick trigeminal ganglion

Project description:The trigeminal ganglion is a critical structure in the peripheral nervous system, responsible for transmitting sensations of touch, pain, and temperature from craniofacial regions to the brain. Trigeminal ganglion development depends upon intrinsic cellular programming as well as extrinsic signals exchanged by diverse cell populations. With its complex anatomy and dual cellular origin from cranial placodes and neural crest cells, the trigeminal ganglion offers a rich context for examining diverse biological processes, including cell migration, fate determination, adhesion, and axon guidance. Avian models have, so far, enabled key insights into craniofacial and peripheral nervous system development. Yet, the molecular mechanisms driving trigeminal ganglion formation and subsequent nerve growth remain elusive. In this study, we performed RNA-sequencing at multiple stages of chick trigeminal ganglion development and generated a novel transcriptomic dataset that has been curated to illustrate temporally dynamic gene expression patterns. This publicly available resource identifies major pathways involved in trigeminal gangliogenesis, particularly with respect to the condensation and maturation of placode-derived neurons, thus inviting new lines of research into the essential processes governing trigeminal ganglion development.

2025-01-01 | GSE282770 | GEO

Effects of Nogo-A deletion on the trigeminal ganglion

Project description:Nogo-A is a major regulator of neural development and regeneration in the central nervous system, but its role in tooth innervation remains largely unknown. Neurons of the trigeminal ganglion innervate the teeth. We showed that Nogo-A is expressed in the trigeminal ganglion and tooth-related nerve fibres. Nogo-A deletion in mice leads to a less complex neuronal network when compared to wild-type animals. Bulk RNA sequencing on the trigeminal ganglia of Nogo-A KO and wild-type mice revealed gene expression changes associated with alterations in neurotrophin signalling and neuronal synaptic formation during the development and maturation of the trigeminal neurons.

2024-12-04 | GSE283391 | GEO

Gene expression profile at single cell level of trigeminal ganglion non-neuronal cells

Project description:Trigeminal ganglion non-neuronal cells contain glial, endothelila, smooth muscle, immune cells and fibroblasts.

2023-12-07 | GSE240432 | GEO

Proteomics of exosomes derived from rat trigeminal ganglion neurons

Project description:Exosomes derived from rat trigeminal ganglion neurons (TGN) were harvested as control group. Exosomes derived from TGN after internalizing exosomes derived from stem cells from human exfoliated deciduous teeth (S-Exo) were harvested as treatment group.

2024-01-22 | PXD048746 |

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine

Project description:The sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes involved remain unclear. We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. These data describe evolutionarily conserved and human-specific gene expression patterns within each trigeminal ganglion cell type, as well as the transcription factors and gene regulatory elements that contribute to cell-type-specific gene expression. We then leverage these data to identify trigeminal ganglion cell types that are implicated both by human genetic variation associated with migraine and two mouse models of headache. This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain.

2022-02-26 | GSE197289 | GEO

The transcriptional landscape of the developing chick trigeminal ganglion

Project description:The transcriptional landscape of the developing chick trigeminal ganglion

| PRJNA1190386 | ENA

Effects of Nogo-A deletion on the trigeminal ganglion

Project description:Effects of Nogo-A deletion on the trigeminal ganglion

| PRJNA1193571 | ENA

RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

Project description:RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

| PRJEB46592 | ENA

RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

Project description:The epigenetic roles in trigeminal neuralgia (TN) still remain unclear. H3K9ac alteration in neuralgia is obscure and controversy. In this study, we established TN rat model via chronic compression, and further treated with 100 mg/kg/d carbamazepine (CBZ). RNA-seq were conducted to investigate the transcriptional profilings in control, TN and TN+CBZ.

2021-08-02 | E-MTAB-10792 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data