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Biomarker discovery in paired mid luteal endometrial biopsies

ABSTRACT: Biomarker discovery in paired mid luteal endometrial biopsies

PROVIDER: PRJNA1030760 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26457900.fastq.gz	Fastqsanger.gz
	SRR26457901.fastq.gz	Fastqsanger.gz
	SRR26457902.fastq.gz	Fastqsanger.gz
	SRR26457903.fastq.gz	Fastqsanger.gz
	SRR26457904.fastq.gz	Fastqsanger.gz

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Biomarker discovery in paired mid luteal endometrial biopsies

Project description:Cell state determination is apparent within the endometrium during the mid-luteal window of implantation. Using previously identified biomarkers of cell states (SCARA5 and DIO2) we performed bulk RNA sequencing on 6 pairs of endometrial biopsies characterised by either normal biomarker expression in both biopsies, or abnormal biomarker expression in one biopsy (low SCARA5 and high DIO2) and normal expression in a second biopsy. We demonstrate that “abnormal cycles” are associated with a distinct gene expression profile when compared to “normal cycles” and have utilised this dataset for biomarker discovery.

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