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Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription

ABSTRACT: Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription

PROVIDER: PRJNA1030912 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26459976_1.fastq.gz	Fastqsanger.gz
	SRR26459976_2.fastq.gz	Fastqsanger.gz
	SRR26459977_1.fastq.gz	Fastqsanger.gz
	SRR26459977_2.fastq.gz	Fastqsanger.gz
	SRR26459978_1.fastq.gz	Fastqsanger.gz

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Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription

Project description:Corticotomy is a clinical procedure targeting alveolar bone to activate regional acceleratory phenomenon (RAP) and promote orthodontic tooth movement (OTM). Corticotomy involves the orchestration of inflammation by macrophages, but the underlying mechanism remains unclear. Here, we identify endoplasmic reticulum (ER) stress sensor activating transcription factor 6 (ATF6) as a critical player modulating pro- and anti-inflammatory macrophage polarization. We show that macrophage-specific ATF6 deletion blocks corticotomy-induced OTM acceleration, while macrophage ATF6 overexpression exaggerates the acceleration effect. Furthermore, the proportion of pro-inflammatory macrophages is positively correlated with ATF6 expression in vitro and in vivo. By RNA-seq and CUT&Tag, we demonstrate that ATF6 interacts with Tnfα promotor and augments its transcription, thereby mediating the effect of TNF signaling pathway in pro-inflammatory macrophage polarization. In summary, ATF6 may aggravate alveolar bone remodeling during corticotomy by promoting Tnfα transcription in macrophages, suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerating orthodontics.

2025-04-09 | GSE245975 | GEO

Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription

2025-04-09 | GSE246048 | GEO

Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription

Project description:Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription

| PRJNA1031204 | ENA

Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing

Project description:Corticision is a common technique to accelerate orthodontic tooth movement; however, not much is known about the underlying mechanisms. In this study, we investigated the mechanism of alveolar tissue remodeling after corticision in a rat model of tooth movement (TM) by analyzing the differential transcriptome

2018-02-13 | GSE94825 | GEO

Mouse periodontal ligament tissue after orthodontic tooth movement

Project description:Mouse periodontal ligament tissue after orthodontic tooth movement for 14 days. Tissue was dissected by a laser microdissection microscope. Samples were analyzed separately at mesial (compression) and distal (tension) sides.

2022-12-16 | PXD030430 | JPOST Repository

Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement

Project description:This study provides a comprehensive examination of the influence of age on osteoclast activity during orthodontic tooth movement, analyzed through the lens of osteoimmunology, identifying key immune molecules and cells involved in the regulation.We identified key molecules that play an important role in orthodontic bone reconstruction by analyzing the differences in immune inflammatory differential gene expression across different age groups. These molecules, which facilitate macrophage migration to the local site and their differentiation into osteoclasts, as well as directly enhance osteoclast differentiation and function, are differentially expressed in young groups, but not in adult groups.

2025-08-20 | GSE299315 | GEO

Gene expression profile at single cell level of alveolar bone during orthodontic tooth movement

Project description:We used single cell RNA sequencing (SCRNA-seq) to analyze the diffenrence in cell population in the alveolar bone before and after orthodntic tooth movement

2025-02-01 | GSE287729 | GEO

Gene expression profile at single cell level of alveolar bone during orthodontic tooth movement

Project description:Gene expression profile at single cell level of alveolar bone during orthodontic tooth movement

| PRJNA1214349 | ENA

Importin-7 Promotes Tension-Induced Osteogenesis by Regulating RUNX2 Nuclear Translocation during Orthodontic Tooth Movement

Project description:Orthodontic tooth movement (OTM) is primarily driven by alveolar bone remodeling, wherein tension-induced osteogenesis plays a central role. Importin7 (IPO7) has been identified as a highly mechanoresponsive nuclear transport receptor (NTR). However, its role in regulating tension-induced osteogenesis during OTM and its underlying mechanism remains elusive. In the present study, cyclic tensile strain and a rat OTM model were used to investigate the role of IPO7. The results revealed that IPO7 was significantly expressed both in vitro and in vivo following exposure to mechanical stretch. Moreover, IPO7 knockdown inhibited tension-induced osteogenesis in BMSCs. Upon mechanical force stimulation, IPO7 translocated from the cytoplasm to the nucleus. Furthermore, immunoprecipitation (IP) coupled with mass spectrometry (MS) was performed and demonstrated that RUNX2 was one of the IPO7-interacting proteins related to osteogenesis. Although RUNX2 has been established to translocate to the nucleus to facilitate osteogenesis, whether it is IPO7 that regulate RUNX2 nuclear input during tension-induced osteogenesis remains to be determined. Then, the interaction between IPO7 and RUNX2 was further validated via co-immunoprecipitation (co-IP) and colocalization assays in BMSCs using immunofluorescence. Taken together, this study demonstrates that IPO7 promotes tension-induced osteogenesis by regulating the nucleoplasmic localization of RUNX2. Thus, targeting IPO7 may represent a prospective therapeutic strategy for enhancing alveolar bone remodeling and the efficacy of orthodontic treatment.

2025-10-06 | PXD061760 | Pride

Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement

Project description:Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement

| PRJNA1273898 | ENA

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