Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Extrachromosomal circular DNA produces regulatory small RNAs involved in zygotic genome remodeling

PROVIDER: PRJNA1032290 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26532572.fastq.gz	Fastqsanger.gz
	SRR26532573.fastq.gz	Fastqsanger.gz
	SRR26532574.fastq.gz	Fastqsanger.gz
	SRR26532575_1.fastq.gz	Fastqsanger.gz
	SRR26532576_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 19

Similar Datasets

a4f81cc9-61ee-4973-af41-41944ce92deb - samples

Project description:Circle-seq data for 21 primary neuroblastoma samples supporting Koche et al. Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma (2020).

| EGAD00001006580 | EGA

7b47e76d-c1f5-447f-ae9d-a634b758e1d1 - samples

Project description:This dataset comprises Circle-seq data for 12 neuroblastoma cell lines supporting Koche et al. Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma (2020).

| EGAD00001006579 | EGA

Promoterless extrachromosomal circular DNA, microDNA, autonomously produce short regulatory RNAs that suppress gene expression

Project description:Promoterless extrachromosomal circular DNA, microDNA, autonomously produce short regulatory RNAs that suppress gene expression

| PRJNA512101 | ENA

Homo sapiens

Project description:Circular extrachromosomal DNA drives massive oncogene expression and chromatin remodeling

| PRJNA506071 | ENA

Project description:extrachromosomal circular DNA in placenta

| PRJNA784191 | ENA

Extrachromosomal circular SUZ12 amplicon dictates retinoblastoma progression through reprogramming H3K27 methylation [eccDNA-seq]

Project description:Extrachromosomal circular DNA (eccDNA) is double-stranded circular DNA that is derived from but independent of chromosomal DNA. Owing to its nonchromosomal inheritance, eccDNA facilitates the amplification of oncogenes and expedites the process of genome evolution in tumor. However, the role of eccDNA in RB remains enigmatic. We combined Circle-Seq and RNA-Seq to identified crucial extrachromosomal circular oncogene amplicons. Herein, we revealed that extrachromosomal circular SUZ12 amplicon regulates H3K27me3 modification during the oncogenic progression of retinoblastoma. Conclusively, our study initially delineated an integrated picture of the eccDNA landscape in retinoblastoma and unveiled a novel SUZ12-containing eccDNA/H3K27me3 oncogenic mechanism where eccDNA dictates retinoblastoma progression through regulating transcription levels of linear DNA.

2023-07-02 | GSE235888 | GEO

Project description:Extrachromosomal circular DNA in Arabidopsis thaliana

| PRJNA497665 | ENA

Project description:Extrachromosomal circular DNA in Arabidopsis thaliana

| PRJNA572559 | ENA

Project description:Human extrachromosomal circular DNA is sequenced by circular sequencing

| PRJNA1121609 | ENA

Effects of nucleases on cell-free extrachromosomal circular DNA

Project description:Effects of nucleases on cell-free extrachromosomal circular DNA

| EGAS00001005873 | EGA