Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Blood single cell transcriptome of paradoxical eczema in psoriasis patients treated with biologics

ABSTRACT: Blood single cell transcriptome of paradoxical eczema in psoriasis patients treated with biologics

PROVIDER: PRJNA1032546 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26537213.fastq.gz	Fastqsanger.gz
	SRR26537214.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Blood single cell transcriptome of paradoxical eczema in psoriasis patients treated with biologics

Project description:Biologics targeting the tumour necrosis factor (TNF) and interleukin (IL)-17/23 axis are highly effective treatments for psoriasis but can result in cutaneous adverse events. The pathogenesis of paradoxical eczema, the occurrence of an atopic dermatitis phenotype after biologic initiation in people with psoriasis, is unknown. Using single cell RNA-seq and mass cytometry, we found increased expression of TNF, interferon (IFN)-γ and IFN-α and their signalling pathways in paradoxical eczema case cell clusters compared with matched psoriasis controls. Genetic variants influencing expression of TNF pathway genes were associated with paradoxical eczema in a separate genotyped cohort, and this association was independent of known atopic risk loci. This suggests that paradoxical eczema has a predominantly type 1 systemic inflammatory signature, and that genetic susceptibility to aberrant TNF pathway signalling could contribute to development of this phenotype during biologic treatment.

2025-05-16 | GSE246326 | GEO

Intra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

Project description:Comparing molecular signatures of psoriasis and eczema in patients co-affected by both diseases provides a comprehensive understanding of disease pathogenesis as well as a diagnostic tool to differentiate these widespread inflammatory skin diseases. In patients affected by both psoriasis and non-atopic or atopic eczema simultaneously (n=24), whole genome expression arrays of psoriasis, eczema, and non-involved skin were performed Arrays MQ_35 and MQ_41 did not pass quality control and thus were not normalized and were excluded from this Series.

2014-05-01 | E-GEOD-57225 | biostudies-arrayexpress

MicroRNA profiling of human healthy, psoriasis and atopic eczema skin samples

Project description:The microRNA expression profile of heathly, psoriasis and atopic eczema skin smaples was compared.

2007-08-16 | E-MEXP-1123 | biostudies-arrayexpress

Risk of Paradoxical Eczema in Patients Receiving Biologics for Psoriasis.

Project description: Not available

| S-EPMC10701661 | biostudies-literature

Intra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

2014-05-01 | GSE57225 | GEO

Gene expression based molecular test as diagnostic aid for the differential diagnosis of psoriasis and eczema in formalin fixed and paraffin embedded tissue, microbiopsies and tape strips

Project description:Development of a real-time PCR based molecular classifier to distinguish psoriasis from eczema in FFPE-fixed skin samples and evaluation of the use of minimally invasive microbiopsies and tape strips for molecular diagnosis.

2023-03-01 | GSE223799 | GEO

Suppression of inflammation in psoriasis blood after IL-17 treatment with ixekizumab

Project description:The effect of anti-IL-17 treatment on systemic inflammation is not fully understand. Using cDNA microarray, genomic analysis methods such as GSEA and ingenuity, we characterized the transcriptional changes in the blood of psoriasis patients afer systemic neutralization of IL-17 compared to baseline (before treatment). We also compared the whole blood-derived transcriptome between psoraisis patients at baseline and healthy volunteers to examine systemic inflammation in psoriasis patients. total RNA was extratced from whole blood from psoriasis patients at baseline and after two weeks of treatment; total RNA was extracted from the whole blood of healthy individuals

2014-03-31 | E-GEOD-55201 | biostudies-arrayexpress

IL-4/IL-13 Inhibitors for Atopic Dermatitis Induce Psoriatic Rash Transcriptionally Close to Pustular Psoriasis

Project description:Dupilumab is an antibody targeting the IL-4/IL-13 receptors indicated for atopic dermatitis patients, but paradoxical psoriasis-like reactions have been reported under treatment. To understand the pathogenesis of DI-Pso, we performed a gene expression profiling study using microarray on skin biopsies of dupilumab-induced psoriasis, plaque psoriasis and AD compared with healthy control skin.

2023-01-16 | GSE185764 | GEO

Skin biopsies from atopic eczema and healthy controls

Project description:The aim of this study was to find disease-associated genes in atopic eczema. Keywords: Skin biopsy, DNA microarray, atopic eczema

2006-10-13 | GSE6012 | GEO

Suppression of inflammation in psoriasis blood after IL-17 treatment with ixekizumab

2014-03-31 | GSE55201 | GEO