Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Exosomal miRNAs as potential early predictors of gestational diabetes mellitus

PROVIDER: PRJNA1032733 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26541754.fastq.gz	Fastqsanger.gz
	SRR26541755.fastq.gz	Fastqsanger.gz
	SRR26541756.fastq.gz	Fastqsanger.gz
	SRR26541757.fastq.gz	Fastqsanger.gz
	SRR26541758.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Serum exosomal miRNA profile in pregnancies with gestational diabetes based on pancreatic β-cell function

Project description:Pancreatic β-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal and placental responses during hyperglycemia. Studies have associated exosomal micro RNAs (miRNAs) with GDM development. To date, no studies have been reported that evaluate the profile of miRNAs present in maternal and placental exosomes in the early stages of gestation from pregnancies that develop GDM. We used microarrays to assess whether early pregnancy maternal and placental exosomal miRNA profiles vary according to pancreatic β-cell function in women who will develop GDM (preGDM).

2024-02-29 | GSE243374 | GEO

Role of Circulating Exosomal miRNAs in early diabetic retinopathy

Project description:To investigate the possibilities of circulating exosomal miRNAs in the early screening and prevention of diabetic retinopathy(DR), and to explore how the exosomal miRNAs functioning in DR. We then performed gene expression profiling analysis using data obtained from small RNA-seq of 3 diabetes mellitus(DM) patients and 3 DR patients.

2023-07-12 | GSE221535 | GEO

Homo sapiens

Project description:Circulating miRNAs for gestational diabetes mellitus

| PRJNA383796 | ENA

Plasma exosomal microRNAs associated with metabolism as early predictor of gestational diabetes mellitus

Project description:The microRNA (miRNA) expression profile of plasma exosome in pregnant women complicated with gestational diabetes mellitus (GDM) has not been fully clarified. In this study, differentially expressed miRNAs in plasma exosomes were identified by high-throughput small RNA sequencing in 12 GDM and 12 normal glucose tolerance (NGT) pregnant women and validated in 102 GDM and 101 NGT pregnant women. A total of 22 exosomal miRNAs were found and five of them were verified by qRT-PCR. Exosomal miR-423-5p was upregulated, while miR-99a-5p, miR-192-5p, miR-148a-3p, and miR-122-5p were downregulated in pregnant women complicated with GDM.

2022-11-09 | GSE192813 | GEO

Identification of Circulating miRNA Alterations in Diabetes Patients Excluding Periodontitis Effects: Insights into Target Gene Downregulation in Diabetic Complications

Project description:Circulating exosomal microRNAs (miRNAs) are important regulators of gene expression in diabetes mellitus (DM). In this study, we analyzed plasma exosomal miRNAs from normal individuals and patients with PD or PD combined with diabetes (PDDM). Differentially expressed miRNAs were identified using small RNA-seq, and their target genes were validated using bulk RNA-seq datasets from tissues related to diabetic complications. Analysis of target genes revealed biologically meaningful pathways that were consistently involved across affected tissues, providing insight into systemic miRNA–mRNA regulation in diabetes.

2025-12-04 | GSE301956 | GEO

Plasma exosomal microRNAs associated with metabolism as early predictor of gestational diabetes mellitus

Project description:Plasma exosomal microRNAs associated with metabolism as early predictor of gestational diabetes mellitus

| PRJNA793254 | ENA

MicroRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood are related to neonatal adiposity

Project description:Maternal body size, nutrition, and hyperglycemia contribute to neonatal body size and composition. There is little information on maternal-fetal transmission of messages which influence fetal growth. We analyzed adipocyte-derived small extracellular vesicular (ADsEV) microRNAs in maternal and cord blood to explore their adipogenic potential. Differential expression (DE) of ADsEV miRNAs in adipose vs. lean neonates was studied before and after adjustment for maternal gestational diabetes mellitus (GDM), adiposity, and vitamin B12-folate status.

2023-03-02 | GSE217933 | GEO

RNA seq from plasma exosome before and after chemoradiotherapy for cervical cancer patients

Project description:We sequenced plasma exosomal RNA obtained from 58 blood samples from 29 cervical cancer patients treated with concurrent chemoradiotherapy (CCRT) followed by intracavitary brachytherapy. The patients with 2018 International Federation of Gynecology and Obstetrics [FIGO] stage IB-IVB at diagnosis were included. The 29 cervical cancer patients had two blood samples for each patient drawn before and after CCRT. Next generation sequencing data from plasma exosome included small RNAs, long non-coding RNAs, and mRNAs, of which miRNAs and mRNAs were used for analysis. The log2 fold change values were calculated between the two samples from each patient to detect miRNAs as predictors of early progression and metastasis. We analysed their biological functions through miRNA-mRNA network analysis after selecting several potential exosomal miRNAs associated with clinical results.

2021-05-23 | E-MTAB-10215 | biostudies-arrayexpress

Single cell RNA sequencing of placenta in patients with gestational diabetes during term pregnancy

Project description:We performed the single cell RNAsequencing in the placental tissues of term pregnancies with gestational diabetes mellitus complicated with macrosomia after cesarean section to explore the transcriptome differences and potential mechanisms of placenta in the process of macrosomia in patients with gestational diabetes. Our research helps to understand placental overgrowth in GDMM and its impact on fetal development, providing new insights into the pathogenesis of GDMM and predicting potential therapeutic interventions.

2025-04-16 | GSE267340 | GEO

Circulating exosomal miRNA signature in pregnancies with gestational diabetes mellitus across gestation

Project description:Circulating exosomal miRNA signature in pregnancies with gestational diabetes mellitus across gestation

| PRJNA472881 | ENA