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ATAC-seq data of miR-195 transduced Ebf1-KO FL-ProB-cells.

ABSTRACT: ATAC-seq data of miR-195 transduced Ebf1-KO FL-ProB-cells.

PROVIDER: PRJNA1033577 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26590049_1.fastq.gz	Fastqsanger.gz
	SRR26590049_2.fastq.gz	Fastqsanger.gz
	SRR26590050_1.fastq.gz	Fastqsanger.gz
	SRR26590050_2.fastq.gz	Fastqsanger.gz
	SRR26590051_1.fastq.gz	Fastqsanger.gz

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ATAC-seq data of miR-195 transduced Ebf1-KO FL-ProB-cells.

Project description:EBF1 is crucial transcription factor in B cell lineage and Ebf1 -/- hematopoietic stem cells are arrest in early B cell development and disable to express CD19. miR-195 transduction is able to overcome Ebf1 deficiency and cause CD19 positive cells. ATAC-seq data of these cells provided a new insight into relationship between early B cell differentiation and micro-RNA regulation.

2024-10-28 | GSE246530 | GEO

RNA- and ATAC-seq data of Wt, Ebf1-KO and Pax5-KO FL-ProB-cells.

Project description:EBF1 and PAX5 are crucial factors for B-cell development. Knock down of either factor leads to an arrest in differentiation. RNA-seq data of WT, Ebf1-/- and Pax5-/- FL-ProB cells allowed for identification of activated and repressed target genes. ATAC-seq data of corresponding cell populations could connect gene activity and chromatin accessibility. This finding provided an explanation to the lineage instability observed in early B-cell progenitors. Taken together, the reported data provide an increased insight into mechanisms governing regulation of stage- and lineage specific transcription in early B-lymphocyte development.

2018-06-08 | GSE92434 | GEO

Analysis of expression profiles in miR-195 transduced Ebf1–/– Lin– cells

Project description:Analysis of expression profiles in miR-195 transduced Ebf1–/– Lin– cells

| PRJNA1034100 | ENA

Analysis of expression profiles in miR-195 transduced Ebf1–/– Lin– cells

Project description:To further investigate whether miR-195 transduction lead Ebf1–/– Lin– cells to develop into later stages than pro B, we have employed microarray expression profiling. For the purpose, we compared B cell and other lineages (T cell, NK cell and myeloid) related gene expressions among these samples.

2024-10-28 | GSE246669 | GEO

Genome-wide occupancy of EBF1-wt & EBF1-H240A

Project description:To study the function of EBF1-H240 residue, genome-wide EBF1 ChIP was performed in A-MuLV transformed pro-B (Ebf1fl/fl;RERTCre) cells transduced with Ebf1wt and Ebf1H240A expressing vectors.

2016-11-21 | GSE87636 | GEO

ATACSeq and genome-wide binding profile of EBF1 and Pax5 to unravel molecular networks driving leukemia in Ebf1+/-Pax5+/- (dHet) B-ALL mice.

Project description:ATACSeq, EBF1 ChIPSeq and Pax5 ChIPSeq of dHet B-ALL, dHet proB and wt proB cells.

2020-10-19 | GSE158671 | GEO

RNASeq analysis to unravel molecular networks driving leukemia in Ebf1+/-Pax5+/- (dHet) B-ALL mice

Project description:To profile gene expression changes in Ebf1+/-Pax5+/- (dHet) leukemic mice, we performed RNASeq analysis in dHet B-ALL, dHet proB and wt proB cells.

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Microarray analysis to unravel molecular networks driving leukemia in Ebf1+/- Pax5+/- (dHet) B-ALL mice

Project description:To profile gene expression changes in Ebf1+/-Pax5+/- (dHet) B-ALL mice, we performed microarray analysis in dHet B-ALL, dHet proB and wt proB cells

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Expression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1

Project description:Foxo1 and Ebf1 deficiency leads to a similar disruption of normal B-cell development at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observed we generated gene expression profiles from both genotypes (with corresponding WT controls). This illustrated a shared gene expression signature in Ebf1/Foxo1 deficient CLPs. Gene expression profiling was done using highly purified (FACS sorted) progenitor cells. Cells were purified from bone marrow of wild-type, Foxo1 deficient and Ebf1 deficient mice. Ebf1 deficient bone marrow was aquired by transplantation of Ebf1 deficient progenitors into irradiated hosts. Populations analysed were CLP LY6D-, CLP LY6D+ and proB cells.

2012-11-01 | E-GEOD-41931 | biostudies-arrayexpress

Microarray analysis to identify genes that are differentially expressed in resting and in LPS-activated splenic B cells of Ebf1+/fl-RERTCre and Ebf1fl/fl-RERTCre mice

Project description:Using resting and LPS-stimulated B cells from mice carrying two Ebf1 alleles flanked with loxP sites and an inducible Cre recombinase, target genes of Ebf 1 and the effect of Ebf1 deletion on the cells was analyzed. Target genes of Ebf 1 and the effect of Ebf1 deletion on the cells was analyzed. Ebf1 fl/fl mice and heterozygote control animals carrying an ER-Cre fusion protein were treated with Tamoxifen-Citrate and were sacrificed for analysis. Resting B cells were sorted and were either left untreated or were stimulated with LPS, followed by RNA extraction for expression analysis. See related Series GSE35915.

2012-04-02 | E-GEOD-36061 | biostudies-arrayexpress

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