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Hippocampus-specific epigenetic profiling of chromatin accessibility after deeper cerebral hypoperfusion in mice

ABSTRACT: Hippocampus-specific epigenetic profiling of chromatin accessibility after deeper cerebral hypoperfusion in mice

PROVIDER: PRJNA1035466 | ENA |

REPOSITORIES: ENA

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Hippocampus-specific epigenetic profiling of chromatin accessibility after deeper cerebral hypoperfusion in mice

Project description:Efforts to understand genetic variability involved in hippocampus damage and glial activation support a role for upstream regulation by epigenetic mechanisms. To investigate hippocampus-specific epigenetic profiling after severe cerebral hypoperfusion in mice

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Project description:Chronic cerebral hypoperfusion (CCH) is a well-known risk factor for vascular dementia and other neurodegenerative disease, for which there are currently no effective medications available. MicroRNA (miRNA) are noncoding RNAS mediating post-translational silencing of genes, and has been extensively studied for their involvement in neurodegenerative disease. However, little is known about their roles in vascular dementia (VaD). In this work, a bilateral common carotid arteries occlusion (2-VO) surgery in rats was employed to induced CCH related cognitive dysfunction. Four months later, the hippocampi were dissected from 2-VO and sham operated rats for high-throughput profiling of miRNAs. Twelve differentially expressed miRNAs were identified according to a cutoff of |log2(Fold Change)|≥1 and p＜0.05. GO analysis of target genes revealed that the most relevant biological processes included the regulatory region nucleic acid binding, histone acetyltransferase binding, organic acid transmembrane transporter activity, L-amino acid transmembrane transporter activity. The cellular structure mainly included histone deacetylation complexes, endosomes, Golgi membranes, etc. And the involved molecular processes mainly included axon development, organ morphogenesis, macromolecular modification, regulation of neuron projection development, neuron development. This study provides a framework for understanding the alternations in hippocampus miRNA profiles underwent hypoxia insult.

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