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Integrated transcriptomic and proteomic analysis revealed the inhibition mechanism of a natural luvangetin from Zanthoxylum avicennae against Fusarium verticillioides

ABSTRACT: Integrated transcriptomic and proteomic analysis revealed the inhibition mechanism of a natural luvangetin from Zanthoxylum avicennae against Fusarium verticillioides

PROVIDER: PRJNA1037161 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26730826_1.fastq.gz	Fastqsanger.gz
	SRR26730826_2.fastq.gz	Fastqsanger.gz
	SRR26730827_1.fastq.gz	Fastqsanger.gz
	SRR26730827_2.fastq.gz	Fastqsanger.gz
	SRR26730828_1.fastq.gz	Fastqsanger.gz

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Integrated transcriptomic and proteomic analysis revealed the inhibition mechanism of a natural luvangetin from Zanthoxylum avicennae against Fusarium verticillioides

Project description:(i) To determine the inhibitory effect of Luvangetin against Fusarium verticillioides and fumonisins production in vitro and in vivo, and (ii) to investigate the mode of action of Luvangetin against Fusarium verticillioides by transcriptomics and proteomics analysis.

2023-11-15 | GSE247362 | GEO

Integrated Proteomic and Metabolomic Profiling Reveals Potential Virulence Factors and Secondary Metabolites in the Secretome of Fusarium verticillioides

Project description:<p>Fusarium verticillioides (F. verticillioides) is an important fungal pathogen known to infect a variety of economically critical crops, especially maize, causing substantial yield reductions and economic losses worldwide. In addition to its direct damage to agricultural productivity, F. verticillioides threatens public health through producing/secreting potent compounds, including the well-known fumonisins (FUMs), which pose significant health threats to both livestock and humans due to their toxicity and carcinogenicity. However, current knowledge about the materials secreted/produced by F. verticillioides, such as secreted proteins and additional secondary metabolites remains limited. In the present study, we conducted an integrated secretome analysis of F. verticillioides at exponential growth stage by using proteomic and metabolomic technologies. The results of the present study showed that proteomic analysis identified 185 proteins, including 138 fungus-specific proteins, GO enrichment of these 138 fungus-specific proteins yielded 24 significant terms spanning carbohydrate/polysaccharide and aminoglycan metabolic/catabolic processes, extracellular and membrane-anchored components, and hydrolase/peptidase activities. Meanwhile, KEGG analysis identified starch and sucrose metabolism as the sole significantly enriched pathway. Metabolomic analysis of medium supernatant showed that a total of 2,352 metabolites were identified, with 110 unique to the medium supernatant of fungal group, including fumonisins (A1, B2, B3, B4), fatty acids, and other bioactive compounds. KEGG pathway enrichment highlighted key metabolic pathways such as TCA cycle, unsaturated fatty acid biosynthesis, and arachidonic acid metabolism. These findings provide new insights into the pathogenic mechanisms of F. verticillioides, suggesting potential virulence factors and metabolic adaptations that contribute to its pathogenicity.</p>

2025-11-12 | MTBLS13312 | MetaboLights

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