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α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells

ABSTRACT: α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells

PROVIDER: PRJNA1039841 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26809212.fastq.gz	Fastqsanger.gz
	SRR26809213.fastq.gz	Fastqsanger.gz
	SRR26815327_1.fastq.gz	Fastqsanger.gz
	SRR26815327_2.fastq.gz	Fastqsanger.gz
	SRR26815328_1.fastq.gz	Fastqsanger.gz

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α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [RNA-Seq]

Project description:Development and lineage choice are driven by interconnected transcriptional, epigenetic and metabolic changes. Specific metabolites, such as α-ketoglutarate (αKG), function as signalling molecules affecting the activity of chromatin-modifying enzymes. However, how metabolism coordinates cell-state changes, especially in human pre-implantation development, remains unclear. Here we uncover that inducing naive human embryonic stem cells towards the trophectoderm lineage results in considerable metabolic rewiring, characterized by αKG accumulation. Elevated αKG levels potentiate the capacity of naive embryonic stem cells to specify towards the trophectoderm lineage. Moreover, increased αKG levels promote blastoid polarization and trophectoderm maturation. αKG supplementation does not affect global histone methylation levels; rather, it decreases acetyl-CoA availability, reduces histone acetyltransferase activity and weakens the pluripotency network. We propose that metabolism functions as a positive feedback loop aiding in trophectoderm fate induction and maturation, highlighting that global metabolic rewiring can promote specificity in cell fate decisions through intricate regulation of signalling and chromatin.

2025-02-27 | GSE247631 | GEO

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [ATAC-Seq]

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α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [scRNA-Seq 2D]

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α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [scRNA-Seq 3D]

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α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [ATAC-Seq]

Project description:α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [ATAC-Seq]

| PRJNA1039843 | ENA

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [RNA-Seq]

Project description:α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [RNA-Seq]

| PRJNA1039845 | ENA

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [scRNA-Seq 2D]

Project description:α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [scRNA-Seq 2D]

| PRJNA1039846 | ENA

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [scRNA-Seq 3D]

Project description:α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells [scRNA-Seq 3D]

| PRJNA1129112 | ENA

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-27 | GSE247634 | GEO

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Project description:We conducted gene expression analysis of naive and polarized macrophages from wild type C57BL6/J mice. In this project, we also compared how glutamine deprivation and production of alpha-ketoglutarate during LPS priming affects gene expression profiles in bone marrow-derived macrophages.

2017-07-03 | GSE99296 | GEO

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