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The effect of A-196 and TMP-269 epigenetic enzyme inhibitor treatments on endothelial cells and fibroblasts

ABSTRACT: The effect of A-196 and TMP-269 epigenetic enzyme inhibitor treatments on endothelial cells and fibroblasts

PROVIDER: PRJNA1040175 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26823408.fastq.gz	Fastqsanger.gz
	SRR26823409.fastq.gz	Fastqsanger.gz
	SRR26823410.fastq.gz	Fastqsanger.gz
	SRR26823411.fastq.gz	Fastqsanger.gz
	SRR26823412.fastq.gz	Fastqsanger.gz

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The effect of A-196 and TMP-269 epigenetic enzyme inhibitor treatments on endothelial cells and fibroblasts

Project description:Epigenetic-based therapy has gained interest with regard to cardiovascular diseases. However, cell-type-specific effects and the limited complexity of cellular interactions in the screening methods causes challenges in finding novel drug candidates. Using a library of epigenetic modulator compounds, we found that A-196 and TMP-269 demonstrated functional effects in a fibrin bead angiogenesis assay. To study how these epigenetic enzyme inhibitors affect genome-wide gene expression profiles, we performed RNA-Seq of human umbilical vein endothelial cells (HUVEC) and human pulmonary fibroblasts (HPF) treated with these compounds.

2025-01-02 | GSE247693 | GEO