Project description:Human data demonstrates loss of function mutations of OGFRL1 are a cause of autosomal recessive forms of cherubism. However, the gene function of OGFRL1 is unknown. We performed scRNAseq to investigate the cell types expressing Ogfrl1 in jawbone tissue.
Project description:Committed perivascular preadipocytes were genetically labelled in transgenic mice expressing GFP under the control of the locus (BAC) for Zfp423, a gene controlling preadipocyte determination. The overall goal was to identify genes differentially expressed between perivascular (PDGFRbeta+) GFP+ cells and perivascualar (PDGFRbeta+) GFP- cells from mouse epididymal adipose tissue.