Project description:Gli1+ progenitors are considered as metaphyseal mesenchymal progenitors in the distal femur and proximal tibia under the growth plate. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of Gli1+ progenitors in response to methylprednisolone.
Project description:We used single cell RNA sequencing (scRNA-seq) to identify femur and tibia osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain.
Project description:Single-nuclei RNA sequencing of cells dissociated from Hindlimb (femur and tibia, from RZ to PHT Region) from E16.5 embryos to identify how catch up grpwuth happens during injury and to to show transcriptional identities of contributors to chondrocytes in p21-overexpression induced injury in unilateral models.