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Metabolic Promotion of Adult and Aging Skeletal Muscle Regeneration by the Serine Biosynthesis Pathway [bulkRNA]

ABSTRACT: Metabolic Promotion of Adult and Aging Skeletal Muscle Regeneration by the Serine Biosynthesis Pathway [bulkRNA]

PROVIDER: PRJNA1046440 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26982973.fastq.gz	Fastqsanger.gz
	SRR26982974.fastq.gz	Fastqsanger.gz
	SRR26982975.fastq.gz	Fastqsanger.gz
	SRR26982976.fastq.gz	Fastqsanger.gz
	SRR26982977.fastq.gz	Fastqsanger.gz

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Metabolic Promotion of Adult and Aging Skeletal Muscle Regeneration by the Serine Biosynthesis Pathway [bulkRNA]

Project description:By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that, branching off from glycolysis, the serine biosynthesis pathway (SBP) is activated in regenerating muscle stem cells (MuSCs). Gene inactivation and metabolomics revealed that Psat1, one of the three SBP enzymes, controls MuSCs activation and expansion of myogenic progenitors through production of the metabolite a-ketoglutarate (a-KG) and the a-KG-generated amino acid glutamine. Genetic ablation of Psat1 in MuSCs resulted in defective expansion of MuSCs and impaired regeneration. Psat1, a-KG, and glutamine were reduced in MuSCs of old mice and myoblasts of old individuals. a-KG or glutamine re-established appropriate muscle regeneration of adult Psat1-/- mice, old mice, and improved proliferation of old human myoblasts. These findings contribute insights into the metabolic role of Psat1 during muscle regeneration and suggest a-KG and glutamine as potential therapeutic interventions to ameliorate muscle regeneration during aging.

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Project description:Metabolic Promotion of Adult and Aging Skeletal Muscle Regeneration by the Serine Biosynthesis Pathway [Cut & Run]

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Project description:By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that, branching off from glycolysis, the serine biosynthesis pathway (SBP) is activated in regenerating muscle stem cells (MuSCs). Gene inactivation and metabolomics revealed that Psat1, one of the three SBP enzymes, controls MuSCs activation and expansion of myogenic progenitors through production of the metabolite -ketoglutarate (-KG) and the -KG-generated amino acid glutamine. Genetic ablation of Psat1 in MuSCs resulted in defective expansion of MuSCs and impaired regeneration. Psat1, -KG, and glutamine were reduced in MuSCs of old mice and myoblasts of old individuals. -KG or glutamine re-established appropriate muscle regeneration of adult Psat1-/- mice, old mice, and improved proliferation of old human myoblasts. These findings contribute insights into the metabolic role of Psat1 during muscle regeneration and suggest -KG and glutamine as potential therapeutic interventions to ameliorate muscle regeneration during aging.

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Smallbone2013 - Serine biosynthesis

Project description:Smallbone2013 - Serine biosynthesis Kinetic modelling of metabolic pathways in application to Serine biosynthesis. This model is described in the article: Kinetic Modeling of Metabolic Pathways: Application to Serine Biosynthesis Kieran Smallbone, Natalie J. Stanford Methods in Molecular Biology. 2013; 985:113-121 Abstract: In this chapter, we describe the steps needed to create a kinetic model of a metabolic pathway using kinetic data from both experimental measurements and literature review. Our methodology is presented by using the example of serine biosynthesis in E. coli. As there are no plots to be reproduced as curation figure, table 6 and 7 that corresponds to steady state concentration of metabolite and steady state fluxes of reactions has been reproduced. This model is hosted on BioModels Database and identified by: BIOMD0000000458 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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Metabolic Promotion of Adult and Aging Skeletal Muscle Regeneration by the Serine Biosynthesis Pathway

Project description:This SuperSeries is composed of the SubSeries listed below.

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